锌对大鼠生长发育及组织核酸和蛋白质代谢的影响

通过大鼠缺锌（ＺＤ）、高锌（ＺＨ）模型，研究对生长发育及组织核酸和蛋白质代谢的影响。结果：（１）ＺＤ、ＺＨ组的体重、体重增长值、饲料效价均低于自由喂养（ＡＬ）组，Ｐ＜０．０１；（２）ＺＤ、ＺＨ组的胸脖、脾脏重量低于ＡＬ组，Ｐ＜０．０１。但其它内脏的重量，组间无显著差异；（３）ＺＤ、ＺＨ组的心、肝、脑、肺、肾、睾丸的内脏指教大于ＡＬ组，但胸脖、脾脏指数则小于ＡＬ组；（４）ＺＤ组的胸腺、脾脏、睾丸、脑细胞小于ＡＬ组，Ｐ＜０．０５或Ｐ＜０．０１；（５）ＺＤ，ＺＨ组的胸腺、脾脏、骨髓细胞增殖指数低于ＡＬ组，Ｐ＜０．０１；ＺＤ组的肝脏、睾丸、脑细胞的增殖指数低于ＡＬ组，Ｐ＜０．０５或Ｐ＜０．０１。（６）ＺＤ组的胸腺、脾脏、睾丸、脑细胞的ＤＮＡ和蛋白质含量低于ＡＬ组，Ｐ＜０．０５或Ｐ＜０．０１；胸腺、脾脏、脑细胞的蛋白质含量低于ＡＬ组，Ｐ＜０．０５或Ｐ＜０．０１；（７）ＺＤ组的血清总蛋白、白蛋白低于ＡＬ组，Ｐ＜０．０１。提示缺锌或高锌均可抑制生长发育及组织核酸和蛋白质代谢

THE INFLUENCE OF ZINC ON GROWTH,DEVELOPMENT AND METABOLISM OF NUcLEIC ACIDS AND PROTEINS OF TISSUES IN RATS

he influence of dietary zinc on growth,development and metabolismof nucleic acids and proteins of various tissues in rats were observed.Thefindings were as follows:(1) The body weight, weight gain and feed effici-ciency of zinc deficiency (ZD)and zinc excessive(ZH) groups were lowerthan those of adequate libitum(AL) group,P<0.01.(2)The weights of thy-mus and spleen of ZD and ZH groups were lower than that of AL group,P<0.01, but weight of other organs had no difference among them. (3)Theindexes of heart,liver,brain,lung,kidney and testis of ZD and ZH groupswere higher than that of AL group,P<0. 01.(4)The cell size of thymus,spleen,testis,brain of ZD and ZH groups was smaller than that of AL gr-oup,P<.0l or P<0.05.(5)Tlie proliferation of thymus, spleen, liver,tes-tis, brain and bone marrow cells of ZD group was lower tlian that of ALgroup,P<0.0l or P<0.05.(6)The DNA contents of thymus,spleen,testisand brain cells of ZD group were lower than that of AL group,P<0.0l orP<0.05. The protein contents of thymus,spleen, brain cells of ZD groupwere lower than that of AL group,P<0.0l or P<0.05.(7)The amounts oftotal protein and albumin in the serum of ZD group were lower than thatof AL group,P<0.0l. It was concluded that both deficient or excessivedietary zinc could suppress the growth,development and metabolism of pro-teins and nucleic acids of tissues.