| 荚果蕨地上部分萜类化学成分研究 |
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| 引用本文： | 朱玲娟,燕菲,陈金鹏,张楠,张雪,姚新生. 荚果蕨地上部分萜类化学成分研究[J]. 中草药, 2015, 46(12): 1737-1741 |
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| 作者姓名： | 朱玲娟 燕菲 陈金鹏 张楠 张雪 姚新生 |
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| 作者单位： | 沈阳药科大学中药学院, 辽宁 沈阳 110016;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;沈阳药科大学中药学院, 辽宁 沈阳 110016;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;沈阳药科大学中药学院, 辽宁 沈阳 110016;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;沈阳药科大学中药学院, 辽宁 沈阳 110016;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;沈阳药科大学中药学院, 辽宁 沈阳 110016;中国医学科学院 北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验室, 北京 100050;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;沈阳药科大学中药学院, 辽宁 沈阳 110016;沈阳药科大学 基于靶点的药物设计与研究教育部重点实验室, 辽宁 沈阳 110016;暨南大学中药及天然药物研究所, 广东 广州 510632 |
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| 基金项目： | 天然药物活性物质与功能国家重点实验室开放课题基金(GTZK201304) |
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| 摘 要： | ![]()
目的研究荚果蕨Matteuccia struthiopteris地上部分的化学成分。方法采用Diaion HP20、硅胶、ODS、Sephadex LH-20柱色谱以及制备高效液相色谱等多种色谱学方法进行分离纯化,并根据理化性质和现代波谱学技术鉴定化合物的结构。结果从荚果蕨地上部分60%乙醇提取物中分离并鉴定12个化合物,其中10个为megastigmane型降倍半萜类化合物,分别鉴定为4,7-megastigmadiene-3,9-diol(1)、blumenolA(2)、去氢催吐萝芙木醇(3)、bridelionol F(4)、bridelionolB(5)、3,5,6-trihydroxy-7-megastigmen-9-one(6)、5β,6α-dihydroxy-3β-(β-D-glucoyranosyloxy)-7-megastigmen-9-one(7)、byzantionoside A(8)、dearabinosyl pneumonanthoside(9)、3-hydroxy-β-damascone glucoside(10),另外2个为倍半萜类化合物,分别鉴定为反枝苋苷ⅣV(11)、icariside C_3(12)。结论化合物1~12均为首次从荚果蕨属植物中分离得到。
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| 关 键 词： | 荚果蕨 megastigmane型降倍半萜类 倍半萜 去氢催吐萝芙木醇 反枝苋苷IV |
| 收稿时间： | 2015-03-05 |
Study on terpenoids from aerial parts of Matteuccia struthiopteris |
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| ZHU Ling-juan,YAN Fei,CHEN Jin-peng,ZHANG Nan,ZHANG Xue and YAO Xin-sheng. Study on terpenoids from aerial parts of Matteuccia struthiopteris[J]. Chinese Traditional and Herbal Drugs, 2015, 46(12): 1737-1741 |
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| Authors: | ZHU Ling-juan YAN Fei CHEN Jin-peng ZHANG Nan ZHANG Xue YAO Xin-sheng |
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| Affiliation: | College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China |
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| Abstract: | ![]()
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| Keywords: | Matteuccia struthiopteris (L.) Todaro megastigmane sesquiterpenoids dehydrovomifoliol amarantholidoside IV |
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