E-cadherin和N-cadherin在原发性肝细胞癌中的表达

目的探讨原发性肝细胞癌(HCC)中E-钙黏附素(E-cadherin)与N-钙黏附素(N-cadherin)的表达情况以及两者表达的相关性,寻找它们与HCC转移的关系。方法采用免疫组化两步法检测46例HCC组织和10例正常肝组织中E-cadherin和N-cadherin的表达。结果46例HCC中E-cadherin呈低表达的有34例(73.9%),N-cadherin呈低表达的有30例(65.2%);10例正常肝组织中两种钙黏附素均呈高表达;E-cadherin和N-cadherin的表达皆与HCC分化程度有关(P<0.05),两者之间的表达强度呈正相关(Spearman秩相关系数r=0.579,P<0.01);对比转移倾向高危组和低危组,E-cadherin及N-cadhein的表达强度组间差别显著(Wilcoxon秩和检验P<0.05),高危组中表达强度更低。结论E-cadherin和N-cadherin在HCC中的表达较正常肝组织低;E-cadherin与N-cadherin呈正相关;两种黏附素的低表达提示HCC的低分化和高转移倾向。

E-cadherin and N-cadherin expression in hepatocellular carcinoma

Objective To explore the expression of E-cadherin and N-cadherin in HCC and the relationship between E-cadherin and N-cadherin,and to seek their correlations to metastasis in HCC. Methods Expression of E-cadherin and N-cadherin was detected in 46 cases of HCC and 10 cases of normal liver specimens by immunohistochemical EnVision.Results In 46 cases of HCC,34 cases(73.9%) and 30 cases(65.2%) showed low expression of E-cadherin and N-cadherin,respectively,whereas all of the 10 cases(100%) showed high expression of the both.The expression of E-casherin and N-cadherin was related with the malignant degree and metastasis potential(P<0.05), and showed positive correlation between each other(r=0.579,P<0.01). Conclusions The expression levels of E-cadherin and N-cadherin in HCC are lower than normal liver specimen.N-cadherin positively correlates with E-cadherin.The lower expression of E-cadherin and N-cadherin suggests poorly differentiated and higher potential of metasbasis.