酸枣仁汤对失眠症疗效及血浆褪黑素水平的影响

目的探讨酸枣仁汤对失眠症的疗效及对血浆褪黑素水平的影响。方法选用酸枣仁汤治疗失眠症,采用匹兹堡睡眠质量指数（PSQI）量表评定睡眠状况,采用放射免疫法测定血浆褪黑素水平,观察其治疗前后的变化,并与正常对照进行比较,统计分析分别采用t检验、F检验和直线相关分析。结果治疗前患者PSQI总分明显高于正常对照组（f=3．282,P=0．002）,治疗后患者PSQI总分下降（r=2．371,P=0．007）;患者组治疗前、治疗后和正常对照组血浆MT水平分别为（45．81±13．23）pg／ml、（49．01±16．53）pg／ml和（54．86±18．35）pg／ml,组间比较有差异显著意义（F=5．004．P=0．009）,治疗前明显低于正常对照组和治疗后MT水平;治疗前MT水平与PSQI总分、睡眠质量因子分、入睡时间因子分分剐呈负相关关系（P〈0．05或P〈0．01）。结论酸枣仁汤治疗失眠有明显的疗效,其作用机制可能与MT水平调节有关。

Efficacy of Ziziphi Spinosae decoction on insomnia and its effect on plasma melatonin levels

Objective To investigate the efficacy of Ziziphi Spinosae decoction on insomnia and it＇s effect on plasma melatonin （MT） level. Methods Ziziphi Spinosae decoction was used for treatment of insomnia, the efficacy was evaluated by PSQI, and the concentration of plasma MT was detected by radio immunoassay in patients before and after treatment, and compared with health volunteers. Data was analyzed by t test, F test and correlation analysis. Results Patients＇ pre--treatment PSQI scores were significantly higher than normal control （t = 3. 282,P = 0. 002）. Post-- treatment PSQI scores, however were obviously lower than pre--treatment （t = 2. 371, P = 0. 007）. The plasma MT levels in pre--trea- ted and post--treated patients and health controls were 45.81± 13.23 （pg/ml）, 49.01±16.53 （pg/ml） and 54.86 ± 18.35 （pg/ml） respectively, there was significant difference among groups （F = 5. 004, P = 0. 009）. Pre--treatment MT level was significantly lower than normal control and post--treatment ; Pre --treatment MT level negatively correlated with PSQI scores, sleep quality and time to fall asleep. Conclusions Ziziphi Spinosae decoction was effective in treatment of insomnia via regulating patients＇ plasma MT levels.