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| 白藜芦醇诱导人皮肤癌细胞系凋亡的可能信号通路 | |
| 引用本文： | 赵冬芝,李小双,孙海梅,张国权,闫继红,周德山. 白藜芦醇诱导人皮肤癌细胞系凋亡的可能信号通路[J]. 基础医学与临床, 2011, 31(5): 534-539 |
| 作者姓名： | 赵冬芝 李小双 孙海梅 张国权 闫继红 周德山 |
| 作者单位： | 首都医科大学,基础医学院,组胚教研室,北京,100069 |
| 基金项目： | 北京市教委创新团队基金 |
| 摘 要： | 目的 探讨白藜芦醇(Res)诱导人皮肤癌细胞系(A431细胞)凋亡的可能信号分子,为临床相关疾病的治疗提供新的实验依据.方法 培养的A431细胞分为:对照组(A组)、Res(B组)、Res加SP600125(C组)以及单纯SP600125组(D组).免疫荧光染色、Western blot及相差显微镜观察等方法检测细胞形... |
| 关 键 词： | 白藜芦醇 A431细胞系 P-JNK JNK easpase-3 |
Potential signal pathway of resveratrol-induced apoptosis in human skin cancer cell line |
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| ZHAO Dong-zhi,LI Xiao-shuang,SUN Hai-mei,ZHANG Guo-quan,YAN Ji-hong,ZHOU De-shan. Potential signal pathway of resveratrol-induced apoptosis in human skin cancer cell line[J]. Basic Medical Sciences and Clinics, 2011, 31(5): 534-539 | |
| Authors: | ZHAO Dong-zhi LI Xiao-shuang SUN Hai-mei ZHANG Guo-quan YAN Ji-hong ZHOU De-shan |
| Affiliation: | ZHAO Dong-zhi,LI Xiao-shuang,SUN Hai-mei,ZHANG Guo-quan,YAN Ji-hong,ZHOU De-shan(Dept.of Histology and Embryology,School of Basic Medical Sciences,Capital Medical University,Beijing 100069,China) |
| Abstract: | Objective To investigate a potential signal molecule of resveratrol(Res)-induced apoptosis of human skin cancer cell line,A431 cells.Methods A431 cells were divided into 4 groups as group A(controls),group B(treated with Res),group C(pre-treated by SP600125) and group D(inhibitor control,SP600125 only).Phase contrast microscopy,Western blot and immunofluorescence staining were used to observe morphology and the expression of caspase-3,BCL-2,BAX,JNK and P-JNK in A431 cells.Results Apoptosis was often found a... |
| Keywords: | P-JNK JNK easpase-3 |
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