鼻息肉患者血清中可溶性细胞间黏附分子-1的水平及临床意义

目的:探讨可溶性细胞间黏附分子-1(sICAM-1)在鼻息肉发病中的作用及糖皮质激素治疗鼻息肉的机制。方法:采用双抗体夹心酶联免疫吸附法(ELISA)测定鼻息肉患者经糖皮质激素全身和局部治疗前、后血清中sICAM-1的含量变化,同时观察糖皮质激素对鼻息肉的治疗效果。结果:①鼻息肉患者血清中sICAM-1的含量高于正常对照组;②经糖皮质激素治疗后,鼻息肉患者血清中sICAM-1含量显著下降,显效组sICAM-1下降的程度大于有效组;③糖皮质激素治疗前、后,患者鼻息肉大小计分减少程度与血清中sICAM-1下降程度成正相关。结论:细胞间黏附分子-1(ICAM-1)在鼻息肉发生发展过程中起着重要作用。糖皮质激素可以通过对抗炎性细胞间黏附而对鼻息肉起治疗作用,血清中sICAM-1的水平变化可作为鼻息肉药物治疗疗效的临床判断指标。

Serum levels and clinical values of soluble intercellular adhesion molecule-1 in patients with nasal polyps

OBJECTIVE: To assess the role of soluble intercellular adhesion molecule-1 (sICAM-1) in etiology of nasal polyps. METHOD: Twenty-nine patients with nasal polyps and 20 healthy control cases were chosen. Their serum sICAM-1 was determined by a sandwich enzyme-linked immunolorbent assay (ELISA). All patients were treated by glucocorticoid, serum sICAM-1 was determined post-treatment again. RESULT: (1) Serum levels of sICAM-1 in patients with nasal polyps were higher than that of control group: (2) Serum levels of sICAM-1 in patients were reduced after glucocorticoid treatment, the decrease of sICAM-1 was more apparent in evident-effect group than in effect group; (3) There was a close correlation between the decrease of polyp-size scores and the decrease of serum sICAM-1. CONCLUSION: The elevated expressions of sICAM-1 in patients with nasal polyps indicate its important role in eosinophil recruitment, which was considered as a representative hallmark for nasal polyps. The sICAM-1 is down-regulated by systemic and topical glucocorticoid treatment and the decrease of sICAM-1 is correlated with clinical effect. To take these lines of evidence together, anti-adhesion therapy may be effective for nasal polyps, serum sICAM-1 levels may be use to monitor the effect of steroid therapy in nasal polyps.