| 吡喹酮杂质的研究 |
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| 引用本文： | 包如胜,唐子英,金美春,余辉红.吡喹酮杂质的研究[J].中国医药工业杂志,2004,35(6):358-359. |
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| 作者姓名： | 包如胜 唐子英 金美春 余辉红 |
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| 作者单位： | 浙江海正药业股份有限公司,浙江,台州,318000 |
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| 摘 要： | 用LC-MS和HPLC法以对照品对照,确定吡喹酮合成过程中产生的主要杂质是(1,11b)-位不饱和的吡喹酮,利用催化氢化法可把含该杂质过量的吡喹酮粗品转化为合格品.
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| 关 键 词： | 吡喹酮 杂质 催化氢化 |
| 文章编号： | 1001-8255(2004)06-0358-02 |
Determination of Related Compounds Praziquantel |
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| Authors: | BAO Ru-Sheng TANG Zi-Ying JIN Mei-Chun YU Hui-Hong |
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| Abstract: | The structure of the main related compound in praziquantel was determined to be 2-(cyclohexylcarbonyl)2,3,6,7-tetrahydro-4H-pyrazino2,1-a]-iso-quinolin-4-one by LC-MS and HPLC with praziquantel reference. The relatedcompound could be transformed to praziquantel by catalytic hydrogenation. |
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| Keywords: | praziquantel related compound catalytic hydrogenation |
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