Nonorgan-specific autoantibodies in individuals infected with type 1 human immunodeficiency virus. |
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| Authors: | A Gentric M Blaschek C Julien J Jouquan Y Pennec J M Berthelot D Mottier R Casburn-Budd P Youinou |
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| Affiliation: | Department of Internal Medicine, Brest University Medical School, France. |
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| Abstract: | Fifty-six human immunodeficiency virus-1-positive asymptomatic carriers were tested for the presence of a variety of nonorgan-specific autoantibodies. Antinuclear antibodies were detected in 34 sera, of which 27 were directed to the mitotic spindle apparatus and all were of the IgG isotype. Anti-Golgi complex, anti-centriole, and anti-vimentin antibodies were also present in 20.4, and 4 sera, respectively. Ten patients had less than 500 CD4-carrying T lymphocytes per cubic millimeter. Nine of them had more than one autoantibody. No correlation could be demonstrated between the number of autoantibodies and the level of serum immunoglobulins. |
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