硫酸镁联合拉贝洛尔治疗妊娠期高血压的临床疗效及其对母婴结局的影响

目的 分析硫酸镁联合拉贝洛尔治疗妊娠期高血压的临床疗效及其对母婴结局的影响。方法 选取2016年8月至2018年10月于西北妇女儿童医院就诊的妊娠期高血压患者180例,对照组与观察组各90例。对照组患者行硫酸镁降压治疗,观察组患者行硫酸镁与拉贝洛尔联合治疗。对比两组患者治疗前后血压、血液流变学以及血浆因子浓度变化,记录两组患者母婴结局。结果 ①治疗后,观察组全血还原黏度、全血黏度、血浆MDA水平均低于对照组(P＜0.05)),NO、SOD水平明显增高(P＜0.05);②观察组患者产后大出血发生率低于对照组(P＜0.05),新生儿宫内窘迫与早产发生率明显低于对照组(P＜0.05)。结论 硫酸镁联合拉贝洛尔治疗妊娠期高血压具有显著的临床疗效,通过血管内皮细胞功能的改善以及氧自由基的降低,使得妊娠期高血压患者的血压及尿蛋白水平得到明显的改善,母婴结局良好且安全性高。

Clinical efficacy,maternal and infant outcomes and prognosis of magnesium sulfate combined with labetalol in the treatment of gestational hypertension

Objective To analyze the clinical efficacy of magnesium sulfate combined with labetalol in the treatment of hypertensive disorder complicating pregnancy and its effect on maternal and infant outcomes.Methods 180 patients with gestational hypertension who were admitted to the Northwest Women and Children Hospital from August 2016 to October 2018 were enrolled,and 90 patients in the control group and the observation group. The patients in the control group were treated with magnesium sulfate and the patients in the observation group were treated with magnesium sulfate and labetalol. Blood pressure,hemorheology and plasma factor concentrations were compared before and after treatment. The maternal and infant outcomes of the two groups were recorded.Results ①After treatment,the whole blood reduction viscosity,whole blood viscosity,plasma MDA level of the observation group were lower than the control group (P<0.05),and the levels of NO and SOD were significantly increased (P<0.05);②Patients in the observation group The incidence of postpartum hemorrhage was lower than that of the control group (P<0.05),and the incidence of intrauterine distress and preterm birth was significantly lower than that of the control group (P<0.05).Conclusion Magnesium sulfate combined with labetalol has significant clinical efficacy in the treatment of hypertensive disorder complicating pregnancy. Through the improvement of vascular endothelial cell function and the decrease of oxygen free radicals,the blood pressure and urine protein levels of hypertensive patients with pregnancy are significantly improved. The baby has a good ending and is safe.