肿瘤微环境在肿瘤细胞有氧糖酵解中的作用

肿瘤的发生发展和细胞代谢异常密切相关。肿瘤细胞摄入大量的葡萄糖,即使有足够的氧份供应,也主要借助糖酵解途径产生能量满足快速生长的需求。肿瘤细胞糖酵解受多方面因素影响,肿瘤微环境即为其中之一。近年来,有证据表明在肿瘤细胞糖代谢中,肿瘤微环境的免疫/炎症因子,转化生长因子β(Transforming growth factor-β,TGF-β)、肿瘤坏死因子α(Tumor necrosis factor alpha,TNF-α)、白细胞介素-4(Interleukin,IL-4)和白细胞介素-6(Interleukin,IL-6)等通过调控肿瘤细胞有氧糖酵解产生的能量与物质使细胞快速增殖,在肿瘤细胞糖代谢中起着至关重要的作用。因此,从肿瘤微环境中的免疫/炎症因子调控肿瘤细胞糖酵解的角度关注肿瘤的发生发展,可能为肿瘤的控制及临床治疗提供新思路。

Effects of tumor microenvironment on aerobic glycolysis of tumor cells

The occurrence and development of tumor are closely related to abnormal cell metabolism.Tumor cells intake a large amount of glucose,and even with enough oxygen supply,they also generate energy primarily through the glycolysis pathway to meet the need of rapid growth.Tumor cell glycolysis is affected by many factors,and the tumor microenvironment is one of them.In recent years,there is evidence that immune/inflammatory factors such as transforming growth factor beta(TGF-β),tumor necrosis factor alpha(TNF- α),interleukin-4(IL-4),and interleukin-6(IL-6)in the microenvironment matrix play a crucial role in the process of glucose metabolism,by regulating the aerobic glycolysis of energy and material to rapidly growth and proliferation of tumor cells.Therefore,the occurrence and development of tumor are focused on coming from the point of view of regulating the glycation of tumor cells with immune/inflammatory factors in the tumor microenvironment,providing new ideas for tumor control and clinical treatment.