食管鳞状癌组织 E-cadherin和 Vimentin的表达与肿瘤浸润和转移的关系

目的　探讨食管鳞状癌 (esophageal squamous cell carcinoma，ESCC) 组织E- 钙黏蛋白（E-cadherin）和波形蛋白（Vimentin）的表达与肿瘤浸润和转移的关系。方法　选取2016 年10 月~2018 年3 月收治的126 例ESCC 患者作为研究对象，采用免疫组化（immunohistochemical，IHC）检测ESCC 患者肿瘤和癌旁正常黏膜组织中E-cadherin 和Vimentin 的表达水平。采用pearson 相关性分析检测ESCC 患者肿瘤和癌旁正常组织中E-cadherin 和Vimentin 的相关性。分析E-cadherin 和Vimentin 与ESCC 患者临床病理特征之间的关系。结果　ESCC 患者癌组织中E-cadherin 的表达水平显著高于癌旁正常黏膜组织（P <0.001），癌旁正常黏膜组织中Vimentin 的表达水平显著高于癌组织(P <0.001)。相关性分析结果显示，ESCC 患者肿瘤组织中E-cadherin 和Vimentin 水平呈显著负相关（r = － 0.574, P <0.001），而癌旁正常组织中E-cadherin 和Vimentin 水平无显著相关性（r =0.096, P =0.510）。临床病理特征分析结果显示，E-cadherin 表达的降低和Vimentin 表达的升高与ESCC 的病理分型、TNM 分期、淋巴结转移和浸润深度均显著相关（P <0.001）。结论　检测E-cadherin 与Vimentin 对ESCC 患者具有潜在的诊断与治疗价值。

Expression of E-cadherin and Vimentin and Its Relationship with Infiltrationand Metastasis of Esophageal Aquamous Carcinoma

Objective　To investigate the relationship between the expression of E-cadherin and Vimentin in esophagealsquamous cell carcinoma (ESCC) and tumor invasion and metastasis. Methods　A total of 126 ESCC patients admitted fromOctober 2016 to March 2018 were selected as study subjects. Immunohistochemistry (IHC) was used to detect the expressionlevels of E-cadherin and Vimentin in tumor and normal adjacent mucosal tissues of ESCC patients. Pearson correlation analysiswas used to detect the correlation between E-cadherin and Vimentin in tumor and adjacent normal tissues of ESCC patients. Therelationship between E-cadherin and Vimentin and the clinicopathological characteristics of ESCC patients was analyzed. Results　The expression level of E-cadherin in the cancer tissues of ESCC patients was significantly higher than that of the normaladjacent mucosa tissues (P <0.001), and the expression level of Vimentin in the normal adjacent mucosa tissues was significantlyhigher than that of the cancer tissues (P <0.001). Correlation analysis results showed that E-cadherin and Vimentin levels intumor tissues of ESCC patients were significantly negatively correlated (r = － 0.574, P <0.001), while there was no significantcorrelation between E-cadherin and Vimentin levels in para-cancer normal tissues (r =0.096, P =0.510). The clinicopathologicalanalysis results showed that the decreased expression of E-cadherin and the increased expression of Vimentin were significantlycorrelated with the pathological classification, TNM stage, lymph node metastasis and infiltration depth of ESCC (P <0.001).Conclusion　Detection of E-cadherin and Vimentin has potential diagnostic and therapeutic value for ESCC patients.