|
|||||
|
|
| 荆豆凝集素(UEA-Ⅰ)受体的定位分布对诊断鼻咽癌前病变的初步观察 | |
| 引用本文： | 冯本澄,戴奕然,肖振德,候景辉. 荆豆凝集素(UEA-Ⅰ)受体的定位分布对诊断鼻咽癌前病变的初步观察[J]. 癌症, 1992, 0(1) |
| 作者姓名： | 冯本澄 戴奕然 肖振德 候景辉 |
| 作者单位： | 中山医科大学肿瘤中心病理室，中山医科大学肿瘤中心病理室，中山医科大学肿瘤中心病理室，中山医科大学肿瘤中心病理室 广州 510060，广州 510060，广州 510060，广州 510060 |
| 摘 要： | 用亲合组织化学技术,以UEA—I,ConA,PNA三种凝集素对30例鼻咽上皮重度不典型增生、化生(癌前病变),70例鼻咽癌及30例正常鼻咽粘膜上皮进行观察对比,了解其分布定位及含量的差异。结果发现:荆豆凝集素(UEA—I)在正常鳞状上皮多呈膜性分布;鼻咽癌癌细胞多呈阴性反应;而鼻咽癌前病变的细胞则显示膜性及胞浆性强阳性反应,与正常上皮及癌巢对比鲜明,UEA—I还能显示间质异常增生的血管,说明它是一种协助诊断鼻咽癌前病变很有希望的一种凝集素。而PNA及ConA则对鼻咽癌前病变的诊断价值不大。 |
| 关 键 词： | 鼻咽癌 癌前病变 凝集素亲合组织化学 |
THE VALUE OF DISTRIBUTED LOCATION OF LECTIN UEA-I RECEPTORS IN THE DIAGNOSIS OF PRECANCEROUS LESION OF NASOPHARYNX |
|
| FFNG Ben-cheng DAI Yi-ran XIAO Zhen-di HOU Jing-hui. THE VALUE OF DISTRIBUTED LOCATION OF LECTIN UEA-I RECEPTORS IN THE DIAGNOSIS OF PRECANCEROUS LESION OF NASOPHARYNX[J]. Chinese journal of cancer, 1992, 0(1) | |
| Authors: | FFNG Ben-cheng DAI Yi-ran XIAO Zhen-di HOU Jing-hui |
| Abstract: | By the use of lectin affinitive histochemical method, the affinity of normal, dysplastic, neoplastic nasopharyngeal epithelium to three kind of lectins (UEA-I, ConA and PNA) were studied. UEA-I (Ulex european Agglutinin-I) displayed membrane distribution in normal squamous epithelium, but most of nasopharyngeal carcinoma cells showed negative reaction to UEA-I Notably, severe dysplastic epithelium (precancerous lesion) exhibited a strong membranous and cytoplasmic affinity, that contrasted sharply with the normal epithelium and carcinoma ceils. The statistkally significant differencein the content and distributed location of lectin UEA-I in these three groups, suggested that UEA-I may be a useful lectin for the diagnosis of precancerous lesion of nasopharynx. But PNA and ConA have no diagnostic Value. |
| Keywords: | Nasopharyngeal carcinoma Precancerous lesion Lectin-affinitive histochemistry |
| 本文献已被 CNKI 等数据库收录！ | |