| 近红外光谱技术在帕金森病大鼠脑组织射频毁损术中的应用 |
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| 引用本文： | 吴琦,杨天明,钱志余,毛雯岚,郭丽娜,何亮.近红外光谱技术在帕金森病大鼠脑组织射频毁损术中的应用[J].现代医学,2008,36(4). |
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| 作者姓名： | 吴琦 杨天明 钱志余 毛雯岚 郭丽娜 何亮 |
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| 作者单位： | 1. 东南大学附属中大医院,神经外科,江苏,南京,210009
2. 南京航空航天大学,生物医学工程系,江苏,南京,210016 |
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| 摘 要： | 目的探索近红外光谱(NIRS)技术用于立体定向靶点毁损术中实时监测的可行性,并观察此过程中NIRS参数的变化规律。方法在大鼠脑纹状体采用两点注入法注入6-OHDA建立帕金森病(PD)大鼠模型;对正常及PD大鼠进行射频毁损,观察并记录脑组织靶点毁损时的NIRS尤其是优化散射系数的变化情况。结果(1)50只大鼠中有40只经阿扑吗啡(APO)诱导后表现为恒定左侧旋转,旋转圈数超过7 r.min-1。(2)射频毁损丘脑腹外侧核(Vim)时,在各温度点下NIRS出现特征性变化曲线。结论利用NIRS实时活体在位监测帕金森大鼠射频神经核团毁损术是科学、可行的,优化散射系数是监测的良好指标。
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| 关 键 词： | 近红外光谱技术 优化散射系数 立体定位技术 帕金森病 神经核团毁损术 大鼠 |
Application of near-infrared spectroscopy technology in studying the damage of rats with Parkinson disease by radiofrequency |
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| WU Qi,YANG Tian-ming,QIAN Zhi-yu,MAO Wen-lan,GUO Li-na,HE Liang.Application of near-infrared spectroscopy technology in studying the damage of rats with Parkinson disease by radiofrequency[J].Modern Medical JOurnal,2008,36(4). |
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| Authors: | WU Qi YANG Tian-ming QIAN Zhi-yu MAO Wen-lan GUO Li-na HE Liang |
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| Institution: | WU Qi1,YANG Tian-ming1,QIAN Zhi-yu2,MAO Wen-lan2,GUO Li-na2,HE Liang1(1.Department of Neurosurgery,Zhongda Hospital,Southeast University,Nanjing 210009,China,2.Department of Biomedical Engineering,Nanjing University of Aeronautics , Astronautics,Nanjing 210016,China) |
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| Abstract: | Objective To explore the feasibility of using near-infrared spectroscopy(NIRS) technology to monitor real-time target in the stereotactic destruction technology and to observe the process of changes in the parameters.Methods The establishment of animal models: inject 6-hydroxydopamine(6-OHDA) into the striatum at two points to establish the rat model of Parkinson disease(PD).Target destruction in near infrared spectroscopy monitoring:reversible radiofrequency ablation was implemented on normal and PD rats.C... |
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| Keywords: | near-infrared spectroscopy reduced scattering coefficient stereotactic technology Parkinson disease ablative procedure rats |
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