实验性肝纤维化血清白蛋白含量变化

目的：研究血清白蛋白含量在肝纤维化形成过程中的变化。方法：用四氯化碳（CCl4)诱发鼠肝纤维化模型，测定CCl4处理前及处理后2、4、6、8周血清白蛋白及肝脏胶原蛋白含量。结果：血清白蛋白含量在CCl4处理后2周明显降低，随后开始增加，到第8周时又出现下降；肝脏胶原蛋白含量在第2周明显增加，并一直保持不变。结论：血清白蛋白含量测定对早期期纤维化的辅助诊断及预后具有重要应用价值。

Content Changes of the Serum Albumin in Rats with CCl4Induced Liver Fibrosis

Objective:To observe the change of serum albumin in live fibrosis. Metheds: Rat liver fibrosis was induced by CCl *#4.The contents of serum albumin and liver collagen were measured in 2?4?6 and 8 weeks after treatment. Results: The contents of serum albumin decreased and Hepatic collagen increased singnificantly in two weeks after treatment, then ,the serum albumin increased ,but decreasd again at the 8 th week.Hepatic collagen kept the same level at the 4 th ,6 th ,and 8 th weeks post-treatment. Conclusions: The serum albumin levels might be an good indicator of early liver fibrosis and its prognosis.