老年性脑神经疾病SPECT血流灌注显像应用研究

用两种灌注显像剂，对84例老年中枢神经系统疾病患者行单光子断层显像（SPEC）研究。其中脑血管疾病53例，痴呆25例（AD17例，MID8例），帕金森氏病6例。79例进行了CT检查并作了比较，结果表明，SPECT脑显像对脑血管疾病有较高的诊断价值。93．3％脑梗塞患者SPECT显像有阳性发现，图像特征为病灶处血流灌注减少所致的放射性减低区，与CT相符，但范围较CT为大。在TIA、脑供血不足及脑动脉硬化中均见到有局部血流减少的表现，较CT为灵敏，但脑出血阳性率略逊于CT。痴呆症的SPECT改变在AD和MID中各有其特征性改变。大多数帕金森氏病患者的大脑和基底节可见到血流减低区，其CT改变不明显。

Research of the Application of SPECT Imagine in Elderly Patients with Central Nervous System Diseases

Eighty-four elderly patients with central nervous system diseases were studied by SPECT imaging, among them, cerebrovascular disease 53 cases, dementia 25 cases(AD 17, MID 8),Parkinson's disease 6 cases. CT scans in 79 cases were performed and compared with SPECT. The detertability of cerebral infarction was 93.3% and the hypoperfused area in SPECT conincided with the respective abnormal areas in CT scans but with greater size. SPECT imagings showed regional cerebral hypoperfusion in TIA, brain arteriolar sclerosis, and were better than CT scans, but in cerebral hemorrhage weren't. SPECT imaging in AD and MID had characteristic changes. Most of the PD patients had cortical and basal ganglia hypoperfusion, while CT stans couldn't find obvious abnormal changes.