西红花酸对多柔比星致大鼠心脏毒性的影响

目的：研究西红花酸减轻多柔比星心脏毒性的作用并探讨其机制。方法：建立多柔比星损伤大鼠心脏模型，灌胃给予西红花酸，观察动物心电图变化，测定血清乳酸脱氢酶（LDH）、肌酸激酶（CK）、超氧化物歧化酶（SOD）、全血谷胱甘肽过氧物酶（GSH—Px）和丙二醛（MDA）的变化，用光镜及透射电镜观察心肌的病理改变。结果：西红花酸可以有效改善多柔比星诱导的大鼠心电图异常，如QRS复合波变宽、Q＆T间期延长、T波高耸以及心率变缓（P〈0．05），阻滞多柔比星引起的总SOD，Cu-Zn-SOD，全血GSH—Px活性降低和LDH，CK活性升高及MDA的升高（P〈0．05）；改善心肌超微结构的病理变化。结论：西红花酸可以减轻多柔比星的心脏毒性。

Effects of crocetin on cardiotoxicity of doxorubicin in rats

Objective:To investigate the effects of crocetin on the cardiotoxicity induced by doxorubicin and its mechanism.Methods: Rats were given intraperitoneal injection of doxorubicin to induce the cardiotoxicity.After continuous oral administration of crocetin,the changes of heart rates,QRS complex,Q-T interval and T wave in healthy rats and doxorubicin-treated rats were measured with electrocardiography(ECG),and the pathological changes of myocardium were observed with light microscope and transmission electron microscope,and enzymes activities(LDH,CK,SOD,GSH-Px)and serum MDA levels were determined.Results: Crocetin can ameliorate the disorder of electrocardiography(QRS complex broadening,Q-T interval elongation,T wave elevation and heart rates decline)(P<0.05),prevent the abnormalities of ultrastructure of myocardium,and inhibit the decrease of T-SOD,Cu-Zn-SOD,GSH-Px activities and increase of LDH,CK and MDA induced by doxorubicin(P<0.05).Conclusion: Crocetin may decrease cardiotoxicity of doxorubicin.