抗精神病药所致代谢综合征的多因素分析

目的 调查使用抗精神病药所导致代谢综合征(MS)的相关因素.方法 对使用抗精神病药的住院精神障碍患者进行问卷调查和实验室测定,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综合征标准.结果 调查了符合入组标准的精神障碍患者365例,抗精神病药所致代谢综合征者为96例占26.3%,Logistic回归分析显示影响抗精神病药所致代谢综合征的因素为药物种类、家族史、年龄、运动程度、腹部肥胖,标准回归系数分别为5.7857,4.5728,3.7643,-2.2534,1.5762.结论 使用抗精神病药的患者具有较高的代谢综合征发病风险,可能的危险因素是药物种类、家族史、年龄、腹部肥胖等,在使用抗精神病药的患者中应注意防治代谢综合征.

Multiple factors related to metabolic syndrome induced by antipsychotic drugs

Objective To analyze the related factors to metabolic syndrome(MS) induced by antipsychotic drugs. Methods Patient's data were collected by the way of face-to-face questionnaire to patients or their guardians, consulting patient's medical record, checking physical or laboratory examination. The diagnosis of MS was established with the criteria of branch of diabetes mellitus of Chinese Medical Association. Results Among 365 inpatients with mental disorders,there were 96 eases(26.3% )suffered from metabolic syndrome. Logistic regression analysis appeared that metabolic syndrome correlated with the category of antipsyehotie drugs, family medical history, age, exercises and abdominal obesity, the standardized regression coefficient was 5. 7857,4. 5728,3. 7643, - 2. 2534,1. 5762, respectively. Conclusions The MS is highly prevalent among patients who use antipsyehotie drugs and is strongly associated with antipsyehotie drugs, family medical history, age and abdominal obesity.