| 血清1,3-β-D葡聚糖和半乳甘露聚糖抗原联合检测对血液肿瘤患者侵袭性真菌感染的早期诊断价值 |
| |
| 引用本文： | 张红宇,孟庆祥,柳金,庞丽萍,王钧,许蕾,冯佳,张文丽,张倩,孙丽华,钟凤鸾,徐海婵,虞积仁. 血清1,3-β-D葡聚糖和半乳甘露聚糖抗原联合检测对血液肿瘤患者侵袭性真菌感染的早期诊断价值[J]. 临床血液学杂志, 2009, 0(3) |
| |
| 作者姓名： | 张红宇 孟庆祥 柳金 庞丽萍 王钧 许蕾 冯佳 张文丽 张倩 孙丽华 钟凤鸾 徐海婵 虞积仁 |
| |
| 作者单位： | 北京大学深圳医院血液科,广东深圳518036 |
| |
| 基金项目： | 深圳市科技局项目资助(No:200703211) |
| |
| 摘 要： | 目的：评价血清1，3—β-D葡聚糖（G）和半乳甘露聚糖（GM）抗原联合检测对血液肿瘤患者侵袭性真菌感染（IFI）的早期诊断价值。方法：42例中性粒细胞减少伴发热，经广谱抗生素治疗无效的血液病患者，根据临床回顾性诊断标准定义阳性和阴性病例。采用ELISA试剂盒检测患者血清G和GM，分别计算GM试验和G试验及联合检测的灵敏度、特异度、阳性和阴性预测值。结果：以I值〉1．0为GM试验阳性，G浓度〉60pg／L为G试验阳性计算，GM试验和G试验联合检测的灵敏度、特异度、阳性和阴性预测值77．8％，90．3％，82．4％，87．5％；G试验的灵敏度和阳性预测值高，但GM试验的特异度高。结论：GM试验和G试验联合检测提高试验的敏感度，减少了假阴性的发生，对早期诊断IFI有一定的临床意义。
|
| 关 键 词： | 真菌感染 葡聚糖类 半乳甘露聚糖 诊断 |
Value of serum galactomannan enzyme immunoassay combine with 1,3 beta-glucan assay for diagnosis of invasive fungal infection in hematological disorders |
| |
| ZHANG Hongyu MENG Qinxiang LIU Jin PANG Liping WANG JunXU Lei FENG Jia ZHANG Wenli ZHANG Qian SUN LihuaZHONG Fengluan XU Haichan YU Jiren. Value of serum galactomannan enzyme immunoassay combine with 1,3 beta-glucan assay for diagnosis of invasive fungal infection in hematological disorders[J]. Journal of Clinical Hematology, 2009, 0(3) |
| |
| Authors: | ZHANG Hongyu MENG Qinxiang LIU Jin PANG Liping WANG JunXU Lei FENG Jia ZHANG Wenli ZHANG Qian SUN LihuaZHONG Fengluan XU Haichan YU Jiren |
| |
| Affiliation: | Department of Hematology;Shenzhen Hospital of Peking University;Shenzhen;518036;China |
| |
| Abstract: | Objective:To evaluate the value of serum galactomannan(GM) enzyme immunoassay combine with 1,3 beta-glucan(G) assay for diagnosis of invasive fungal infection(IFI) in hematological disorders.Method:Blood samples were obtained from 42 patients with neutropenic hematological disorder,fever and shown no response to broad-spectrum antibiotics therapy.Serum concentration of GM and G were detected by enzyme linked immunosorbent assay.The proven IFI and non-IFI patients were defined by retrospective clinical analy... |
| |
| Keywords: | fungal infection glucans galactomannan diagnosis |
| 本文献已被 CNKI 维普 等数据库收录！ |
