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| 原发性肝癌组织中血管内皮生长因子、微血管密度检测 | |
| 引用本文： | 陈永杰,付艳忠,赵志华.原发性肝癌组织中血管内皮生长因子、微血管密度检测[J].郑州大学学报(医学版),2007,42(5):925-927. |
| 作者姓名： | 陈永杰 付艳忠 赵志华 |
| 作者单位： | 1. 平顶山煤业集团总医院传染病科,平顶山,467000 2. 焦作市第二人民医院外科,焦作,454150 3. 郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室,郑州,450052 |
| 摘 要： | 目的:探讨原发性肝癌组织中CD105和血管内皮生长因子(VEGF)的表达及两者之间的关系.方法:采用免疫组化SP法对51例肝癌(高分化14例,中分化26例,低分化11例;有门静脉癌栓18例,无门静脉癌栓33例)手术切除标本组织的微血管密度(MVD)及VEGF进行检测,并分析2者与肝癌临床病理特征的关系.结果:肝癌组织MVD及VEGF的表达均与肝癌的分化程度、转移有关(P＜0.05).肝癌组织中MVD与VEGF的表达呈正相关(P＜0.05).结论:原发性肝癌组织中VEGF和MVD的高表达可作为反映原发性肝癌分化程度及转移的有效指标. |
| 关 键 词： | 原发性肝癌 微血管密度 血管内皮生长因子 CD105 |
| 修稿时间： | 2006-09-15 |
Detection of MVD and VEGF in hepatocellular carcinoma tissue |
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| CHEN Yongjie,FU Yanzhong,ZHAO Zhihua.Detection of MVD and VEGF in hepatocellular carcinoma tissue[J].Journal of Zhengzhou University: Med Sci,2007,42(5):925-927. | |
| Authors: | CHEN Yongjie FU Yanzhong ZHAO Zhihua |
| Abstract: | Aim:To explore the relationship between microvessel density(MVD) and VEGF in hepatocellular carcinoma tissue.Methods:MVD and the expression of VEGF in 51 specimens of hepatocellular carcinoma tissue were detected by immunohistochemical SP method.Results:There was a positive correlation between MVD and VEGF(P<0.05).MVD and the expression of VEGF were closely associated with the pathological differentiation and metastasis of hepatocellular carcinoma(P<0.05).Conclusion:The higher level of MVD and the expression of VEGF in hepatocellular carcinoma tissue can be used as indicators for differentiation and metastasis of hepatocellular carcinoma. |
| Keywords: | hepatocellular carcinoma MVD VEGF CD105 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |