血清趋化素水平与代谢综合征的相关性研究

目的 探讨血清趋化素（Chemerin）水平与MS的相关性. 方法 选取非MS（Non-MS）组57例,MS组117例及健康对照（NC）组90名,按Chemerin水平从低到高分为Ter1、Ter2和Ter3亚组.所有研究对象行75 g OGTT和胰岛素释放试验,检测血脂、血清Chemerin、高敏C反应蛋白（hsC-RP）等相关生化指标. 结果 MS组血清Chemerin水平高于Non-MS组和NC组（P＜0.01）.从Ter1到Ter3亚组,BMI、WC、WHR、SBP、FPG、2 hPG、HbA1 c、FIns、HOMA-IR、TG、hsC-RP水平依次升高,HDL-C水平依次降低,MS的患病率依次增加（P＜0.05）.Chemerin与BMI、WC、WHR、SBP、FPG、2 hPG、HbA1 c、FIns、2 hIns、HOMA-IR、TG及hsC-RP呈正相关（P＜0.05）,与HDL-C、胰岛β细胞功能指数（HOMA-β）呈负相关（P＜0.01）.Logistic逐步回归分析显示,Chemerin是MS的独立危险因素（OR=2.197,P＜0.01）.受试者工作曲线（ROC）曲线提示Chemerin预测MS的界值为72.4 ng/ml.结论 Chemerin与MS的发生相关,可作为MS的独立预测指标之一.

The relationship between the level of serum chemerin and metabolic syndrome

Objective To investigate the relationship between the levels of serum chemerin and metabolic syndrome（MS）.Methods 264 subjects were divided into MS group（n=117）,non-MS group （n=57）,and normal controls（NC） group（n=90）.All the subjects were divided into three subgroups：Ter1,Ter2 and Ter3 according to the levels of serum chemerin.A 75 g OGTT and insulin releasing test were performed.Mean-while,blood lipid,serum chemerin,hsC-RP and other items were measured.Results The serum chemerin was higher in MS group than in non-MS group and NC group.The level of BMI,WC,WHR,SBP,FPG,2 hPG,HbA1 c,FIns,HOMA-IR,TG was in turn increased from Ter1 to Ter3 Subgroup,the level of hsC-RP and the prevalence of MS were in turn increased,while HDL-C was decreased（P〈0.05）.Chemerin was positively correlated with BMI,WC,WHR,SBP,FPG,2 hPG,HbA1 c,FIns,2 hIns,HOMA-IR,TG and hsC-RP （P 〈 0.05）,and negatively correlated with HDL-C,HOMA-β（P〈0.01）.Logistic regression analysis showed serum chemerin was positively associated with MS（OR=2.197,P〈0.01）.The area under ROC curve suggested that MS-predicting chemerin cut-off point was serum chemerin 72.4 ng/ml.Conclusion Serum chemerin is associated with the occurrence of MS and might be an independent predictor for MS.