脑卒中急性期并医院感染患者血白细胞及炎性细胞因子表达水平研究

目的：探讨脑卒中急性期并医院感染患者血白细胞及炎性细胞因子的表达水平，方法：1908例脑卒中急性期患者进行了血白细胞计数，内皮素（ET），一氧化氮（NO）和白介素8（IL－8）含量的检测。结果：发生医院感染98例，脑出血和脑梗死医院感染率分别为5．96％、4．54％，常见的感染部位以下呼吸道和泌尿道为主，两种类型疾病间无显著差异（P＞0．05）；医院感染组血白细胞数，ET和IL－8含量均显著高于非医院感染组，而NO含量则显著降低，差异有显著性意义（P＜0．01）。结论：急性脑卒中患者是医院感染高危人群，对其进行血白细胞计数、ET、NO和IL－8含量的分析必将有助于临床医师及早发现并积极预防医院感染的发生。为治疗手段的改进或寻找新的治疗措施提供指导。

Blood Leukocyte Count and Expression of Inflammatory Cytokines in Acute Brain Stroke Patients with Hospital Infection

OBJECTIVE To explore the blood leukocyte count and expression of inflammatory cytokines in acute brain stroke patients with hospital infection. METHODS In total of 1908 cases of acute brain stroke patient the blood leukocyte endothelins(ET), nitric oxide(NO), and IL 8 were analyzed. RESULTS From them 98 cases happened hospital infection, the common locations of infection were lower respiratery tract and urinary tract, the rates of cerebral hemorrhage and cerebral infarction were 5.96% and 4.54%, respectively. No significant difference was existed in two types (P>0.05). Compared with those of the non hospital infection group, the blood leukocyte, ET and IL 8 in hospital infection one were elevated and NO was decreased significantly (P<0.01). CONCLUSIONS The blood leukocyte, ET, NO and IL 8 analyzed among acute brain stroke patients being the high risk people in hospital infection, were contribution to physicians early finding and taking effective therapies to prevent the hospital infection.