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| HPLC法测定非布丙醇胶丸中主药的含量 | |
| 引用本文： | 史国兵,李艳,华威,赵庆春. HPLC法测定非布丙醇胶丸中主药的含量[J]. 中国药房, 2007, 18(19): 1494-1495 |
| 作者姓名： | 史国兵 李艳 华威 赵庆春 |
| 作者单位： | 1. 沈阳军区总医院药剂科,沈阳市,110016 2. 沈阳药科大学,沈阳市,110016 |
| 摘 要： | 目的:建立以高效液相色谱法测定非布丙醇胶丸中主药含量的方法。方法:色谱柱为SphensorbC18,流动相为甲醇-水(65∶35),流速为1.0mL.min-1,检测波长为270nm,进样量为10μL。结果:非布丙醇检测浓度的线性范围为0.2～1.6mg.mL-1(r=0.9999);平均回收率为103.77%(RSD=1.85%)。结论:本方法操作简便、结果准确,可用于该制剂的质量控制。 |
| 关 键 词： | 高效液相色谱法 非布丙醇 胶丸 含量测定 |
| 文章编号： | 1001-0408（2007）19-1494-02 |
| 收稿时间： | 2007-04-06 |
| 修稿时间： | 2007-04-062007-04-26 |
Determination of Principal Agent in Febuprol Pills by HPLC |
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| SHI Guobing,LI Yan,HUA Wei,ZHAO Qingchun. Determination of Principal Agent in Febuprol Pills by HPLC[J]. China Pharmacy, 2007, 18(19): 1494-1495 | |
| Authors: | SHI Guobing LI Yan HUA Wei ZHAO Qingchun |
| Abstract: | OBJECTIVE:To develop a HPLC method for the determination of the principal agent in febuprol pills.METHODS:The principal agent was separated on Sphensorb C18 column with mobile phase consisted of methanol-water(65∶35).The flow rate was 1.0 mL·min-1;the UV detection wavelength was 270 nm and the sample size was 10μL.RES-ULTS:The standard curve of febuprol was linear over the range of 0.2～1.6 mg·mL-1(r=0.999 9).The average recovery of febuprol was 103.77% with RSD at 1.85%.CONCLUSION:This method is simple and accurate,and it can be used as a quality control for febuprol pills. |
| Keywords: | HPLC Febuprol Pill Contents determination |
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