嵌合抗原受体 T 细胞治疗原发性肿瘤的优势与研究进展

嵌合抗原受体 （Car） T 细胞因不仅具有较强特异性识别肿瘤抗原的特性， 还具有杀伤性、 亲和力高等优点，因而受到较多的关注。尽管其在抗肿瘤方面发挥了很多优势， 但是仍存在不足之处， 需要进一步优化来提高其临床应用的安全性。本研究对 Car T 细胞结构及其生物功能、 治疗流程、 应用进展以及应用风险进行综述， 为进一步在临床开展 Car T 免疫治疗提供参考。

The advantages and research progress of T cells of the chimeric antigen receptor in the treatment of primary tumors

Chimeric antigen receptor (Car) T cells, not only have the characteristics of strong specific recognition of tumor antigens, but also have destruction and high affinity advantages, thus receiving more attention. Although it has played a lot of advantages in anti-tumor, it still has some shortcomings, which needs to be further optimized to improve the safety of its clinical application. In this study, The cell structure and biological function, treatment process, application development and application risk of Car T cells are reviewed, which provide references for further clinical immunotherapy of Car T.