| 盐酸小檗碱对环孢素A在大鼠小肠吸收的影响 |
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| 引用本文： | 熊磊,辛华雯,吴笑春,李罄,余爱荣,沈杨,苏丹.盐酸小檗碱对环孢素A在大鼠小肠吸收的影响[J].华南国防医学杂志,2008,22(3):14-16. |
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| 作者姓名： | 熊磊 辛华雯 吴笑春 李罄 余爱荣 沈杨 苏丹 |
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| 作者单位： | 广州军区武汉总医院临床药理科,武汉430070 |
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| 摘 要： | 目的研究盐酸小檗碱（berberine chloride，Ber）对环孢素A（cyclosporin A，CsA）小肠吸收的影响。方法三组大鼠分别以CsA试液、含Ber 100mg·L^-1的CsA试液、含Ber200mg·L^-1的CsA试液，进行在体肠段吸收实验，HPLC法测定CsA浓度。结果与单用CsA相比，空肠段合用Ber组CsA吸收率有明显增加，回肠段合用Ber组CsA吸收无明显变化。结论Ber对CsA小肠吸收有促进作用。
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| 关 键 词： | 盐酸小檗碱 环孢素A 小肠吸收 |
Effect of Berberine Chloride on Absorption Rate of Cyclosporin A by Small Intestine in Rat |
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| Institution: | XIONG Lei , XIN Hua-wen , WU Xiao-chun , et al.(Department of Clinical Pharmacology, Wuhan General Hospital, Guangzhou Military Command , Wuhan Hubei 430070, China) |
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| Abstract: | Objective To study the effect of berberine chloride （Ber） on absorption rate of cyclgsporin A（CsA） by small intestine in rat. Methods The intestinal absorption was investigated by in situ perfusion in rats. The test solution were CsA solution,CsA solution contain 100mg·L^-1 Bet and CsA solution contain 200mg·L^-1 Bet respectively. Concentration of CsA was determined by high performance liquid chromatography （HPLC）. Results Compared with CsA group, the absorption rate of CsA significantly increased in jejunal segment and didn＇t have significant change in ileum segment. Conclusion Ber can accelerate absorption of CsA in small intestine. |
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| Keywords: | Berberine chloride Cyclosporin A Intestinal absorption |
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