胰性脑病的研究现状

目的 介绍急性胰腺炎并发胰性脑病的研究现状。方法 经检索收集有关资料，对胰性脑病相关问题进行文献综述。结果 （1）胰性脑病雪生率为11%-53%。（2）胰腺酶大量吸收入血，并通过血脑屏障造成脑损害是其主要发病机理；（3）脑组织病理检查发现有脱髓鞘化现象；（4）主要临床表现为一过性精神错乱，意识障碍和神经衰弱样征候群等3组精神经症状群；（5）治疗方法包括原发病治疗、甲磺酸加贝酯等抗胰酶治疗以及对症治疗等。结论 胰性脑病是重症急性胰腺炎危险并发症之一，预后极差；血清髓鞘硷性蛋白值升高可望成为胰性脑病可靠的早期诊断生化指标；甲磺酸加贝酯是防治胰性脑病很有前途的酶抑制剂。

Current research on pancreatic encephalopathy

Objective To introduce the current progress of research on pancreatic encephalopathy(PE). Methods Collecting related articles to make this paper.Results (1) The reported incidence of PE was from 11% to 53%. (2).The main pathogenisis of PE was large quantity of enzymes, which were secreted by the pancreas, entering the blood and crossing the blood brain barrier resulting in brain damage. (3).The demyelination could be seen on the brain pathologically. (4).The main clinical features of PE were temporal confusion, coma and neurasthenic syndrome. (5).The treatments of PE include treating underline disease, trying gabexale mesilate(Foy), a new special enzyme inhibitor, and the symptom control treatment. Conclusions PE is a dangerous complication of pancreatitis with a very bad prognosis. Evaluated myelin basic potein(MBP)may be a early, reliable biochemical parameter for diagnosis of PE. A special enzyme inhibitor Foy may be very useful in treating PE.