5-HT2C receptor agonists with potential anorectic activity |
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| Authors: | Goo Yoon Hee Jin Jeong Jeong Ju Kim Seung Hoon Cheon |
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| Affiliation: | College of Pharmacy and Research Institute of Drug Development, Chonnam National University, 300 Yongbong-Dong, BukGu, Gwangju 500-757, Korea. |
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| Abstract: | ![]()
Substituted 2,3,4,4a-tetrahydropyrazino[2,1-c][1,4]benzoxazin-5-(1H)-ones were synthesized and evaluated as 5-HT(2C) receptor agonists for the possible treatment of obesity. A number of compounds exhibited 5-HT(2C) agonist binding activity with compound 19 showing the most potent in vitro activity. |
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| Keywords: | 5HT2C receptor agonist Pyrazinobenoxazinone Anorectic Obesity |
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