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| 核酸适配体类抗HIV-1药物的研究进展 | |
| 引用本文： | 刘涛,缪有盼,吴可柱,李爱秀. 核酸适配体类抗HIV-1药物的研究进展[J]. 药学进展, 2009, 33(1): 1-6. DOI: 10.3969/j.issn.1001-5094.2009.01.001 |
| 作者姓名： | 刘涛 缪有盼 吴可柱 李爱秀 |
| 作者单位： | 1. 中国人民武装警察部队医学院,基础医学部药物设计实验室,天津,300162 2. 中国人民武装警察部队医学院,基础医学部药物设计实验室,天津,300162;中国人民武装警察部队医学院,职业与环境危害生物标志物天津市重点实验室,天津,300162 |
| 基金项目： | 国家自然科学基金，天津市科技攻关计划重点科技攻关专项基金 |
| 摘 要： | 核酸适配体是指能特异结合蛋白质或其它小分子物质的寡核苷酸片段，可通过对某些酶或蛋白因子的抑制达到抗病毒的目的。近年来，核酸适配体类药物的研发已经取得了进展，尤其是在抗艾滋病病毒方面，此类药物展现出了广阔的临床应用前景。目前，核酸适配体类抗HIV-1药物按作用机制可分为抑制HIV-1逆转录酶的适配体、抑制HIV-1核糖核酸酶H的适配体和抑制HIV-1 Tat蛋白介导的反式激活的适配体。介绍这3种核酸适配体类抗HIV-I药物的有关研究情况。 |
| 关 键 词： | 核酸适配体 HIV-1逆转录酶 核糖核酸酶H 反式激活因子 |
Advances in Research on the Aptamers anti-HIV Drugs |
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| LIU Tao,MIAO You-pan,WU Ke-zhu,LI Ai-xiu. Advances in Research on the Aptamers anti-HIV Drugs[J]. Progress in Pharmaceutical Sciences, 2009, 33(1): 1-6. DOI: 10.3969/j.issn.1001-5094.2009.01.001 | |
| Authors: | LIU Tao MIAO You-pan WU Ke-zhu LI Ai-xiu |
| Affiliation: | LIU Tao, MIAO You-pan, WU Ke-zhu, LI Ai-xiu (1. Drug Design Laboratory of the Basic Science Department, Medical College of Chinese People＇s Armed Police Force, Tianjin 300162, China; 2. Tianjin Key Laboratory for Biomarkers of Occupational and Envi- ronmental Hazard, Medical College of Chinese People＇s Armed Police Force, Tianjin 300162, China) |
| Abstract: | Aptamers are oligonucleotides which can bind specifically to proteins and micromolecules, and have actions of anti-HIV by inhibiting some enzymes or protein factors. Recently, there are important progresses in R＆D of aptamers drugs, especially in the treatment for AIDS. In this review, three kinds of aptamers with different anti-HIV-1 mechanisms were discussed. |
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