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| 双歧杆菌对实验性大肠癌血管形成的影响 | |
| 引用本文： | 郑昌京,王立生,李俊达,夏韶华,陈观榕. 双歧杆菌对实验性大肠癌血管形成的影响[J]. 海南医学, 2004, 15(2): 15-16 |
| 作者姓名： | 郑昌京 王立生 李俊达 夏韶华 陈观榕 |
| 作者单位： | 深圳市福田人民医院消化内科,广东,深圳,518033;深圳市人民医院消化内科,广东,深圳,518020 |
| 摘 要： | 目的 从血管形成这一角度探索青春型双歧杆菌的抑瘤机理。方法 以大肠癌裸鼠移植瘤为动物模型,用免疫组化法检测大肠癌组织血管内皮生长因子(VEGF)的表达及其微血管密度(MVD)。结果 双歧杆菌注射组大肠癌VEGF的阳胜细胞密度和MVD的数量均明显低于肿瘤对照组(P<0.01)。结论青春型双歧杆菌能抑制大肠癌的血管形成,其途径可能是下调VEGF的表达。 |
| 关 键 词： | 双歧杆菌 大肠癌 血管内皮生长因子 微血管密度 |
| 文章编号： | 1003-6350(2004)02-0015-02 |
Influence of bifidobacteria on the angiogenesis of experimental large bowel carcinoma |
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| ZHENG Chang-jing,WANG Li-sheng,Li Jun-da,et al.. Influence of bifidobacteria on the angiogenesis of experimental large bowel carcinoma[J]. Hainan Medical Journal, 2004, 15(2): 15-16 | |
| Authors: | ZHENG Chang-jing WANG Li-sheng Li Jun-da et al. |
| Abstract: | Objective To explore the antitumor mechanisms of bifidobacteria adolescence in view of angiogenesis. Methods The vascular endothelial growth factor (VEGF) and microvessel density (MVD)of large bowel carcinoma were detected by using immunohistochemical method depending on the animal model of large bowel carcinoma nude mouse transplantation.Results The positive cell density of VEGF and the number of MVD in bifidobacterium injection group were significantly lower than those in tumor control group (P<0.01) .Conclusions Bifidobacteria adolescence could inhibit the angiogenesis of large bowel carcinoma, and its pathway was to down-regulate the expression of VEGF possibly. |
| Keywords: | Bifidobacterium Large bowel carcinoma Vascular endothelial growth factor Microvessel density. |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |