Salivary 3‐methoxy‐4‐hydroxyphenylglycol increases after awakening in healthy young adults |
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| Authors: | Nagisa Sugaya Shuhei Izawa Ryuichiro Yamamoto Namiko Ogawa Jumpei Yajima Hisayoshi Okamura Satoshi Horiuchi Akira Tsuda Shinobu Nomura |
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| Affiliation: | 1. Department of Epidemiology and Public Health, Graduate School of Medicine, Yokohama City University, Yokohama, Japan;2. Health Administration and Psychosocial Factor Research Group, National Institute of Occupational Safety and Health, Kawasaki, Japan;3. Division of Clinical Psychology, Health Care and Special Support, Graduate School of Education, Joetsu University of Education, Joetsu, Japan;4. Graduate School of Human Sciences, Waseda University, Tokorozawa, Japan;5. Department of Human Studies, Beppu University, Beppu, Japan;6. Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, Kurume, Japan;7. Japan Society for the Promotion of Science, Tokyo, Japan;8. Health Sciences University of Hokkaido, Sapporo, Japan;9. Faculty of Literature, Kurume University, Kurume, Japan;10. Faculty of Human Sciences, Waseda University, Tokorozawa, Japan |
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| Abstract: | Levels of 3‐methoxy‐4‐hydroxyphenylglycol (MHPG) may reflect central noradrenergic activity. In this study, we investigated salivary MHPG changes after awakening, and explored their relationships with cortisol and peripheral autonomic activity. The participants were 25 college students. Saliva samples were collected on awakening and 30 min after awakening to determine MHPG and cortisol. Ambulatory electrocardiograms were obtained to assess heart rate, cardiac sympathetic index (CSI), and cardiac vagal index (CVI) before and after awakening. MHPG levels increased significantly during the first 30 min after awakening. Similarly, cortisol, heart rate, and CSI increased during the 30 min after awakening, but changes in MHPG did not correlate with changes in cortisol, heart rate, CSI, and CVI during that period. This study demonstrated that salivary MHPG levels increase after awakening, in common with cortisol, heart rate, and cardiac sympathetic activity. |
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| Keywords: | MHPG Saliva Awakening Central noradrenergic metabolism |
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