葆宫止血颗粒联合去氧孕烯炔雌醇治疗功能失调性子宫出血的疗效观察

目的探讨葆宫止血颗粒联合去氧孕烯炔雌醇治疗功能失调性子宫出血的临床疗效。方法选取2015年3月—2016年1月在郑州大学第五附属医院接受治疗的功能失调性子宫出血患者84例,随机分为对照组(42例)和治疗组(42例)。对照组患者口服去氧孕烯炔雌醇片,据阴道流血量的不同,给予不同的用药量,出血量较多者口服去氧孕烯炔雌醇1片/次,每隔8小时一次;出血量较少者1片/次,每12小时1次;血止后继续服用3 d后,渐减量至1片/次,1次/d。治疗组在对照组的基础上口服葆宫止血颗粒,1袋/次,3次/d。两组患者均治疗3个月经周期。治疗后,观察两组的临床疗效,比较两组子宫内膜厚度、出血控制时间、完全止血时间和性激素水平的变化。结果治疗后,两组的总有效率分别为80.95%、97.62%,两组总有效率比较具有统计学意义(P0.05)。治疗后,治疗组子宫内膜厚度、出血控制时间、完全止血时间均显著小于对照组(P0.05)。两组患者血清E2、P、FSH和PRL水平显著降低,同组治疗前后差异具有统计学意义(P0.05),且治疗组上述指标改善更明显,两组比较差异具有统计学意义(P0.05)。结论葆宫止血颗粒联合去氧孕烯炔雌醇治疗功能失调性子宫出血效果显著,可明显改善患者临床症状和性激素水平,具有一定的临床推广应用价值。

Clinical observation of Gongbao Zhixue Granules combined with desogestrel ethinylestradiol in treatment of dysfunctional uterine bleeding

Objective To investigate the clinical curative effect of Gongbao Zhixue Granules combined with desogestrel ethinylestradiol in treatment of dysfunctional uterine bleeding. Methods Patients (84 cases) with dysfunctional uterine bleeding in The Fifth Affiliated Hospital of Zhengzhou University from March 2015 to January 2016 were randomly divided into control group (42 cases) and treatment group (42 cases). Patients in the control group were po administered with Desogestrel and Ethinylestradiol Tablets. Different dosage was given based different vaginal bleeding amount. Patients with more vaginal bleeding amount were po administered with Desogestrel and Ethinylestradiol Tablets, 1 tablet/time, once every 8 h. Patients with less vaginal bleeding amount were po administered with Desogestrel and Ethinylestradiol Tablets, 1 tablet/time, once every 12 h. Desogestrel and Ethinylestradiol Tablets were continued for 3 d after the bleeding stopped. And the dosage was decreased to 1 tablet/time, once daily. Patients in the treatment group were po administered with Gongbao Zhixue Granules, 1 bag/time, three times daily. Patients in two groups were treated for 3 menstrual cycles. After treatment, the clinical efficacy was evaluated, and endometrial thickness, bleeding control time, and complete hemostasis time, and sex hormone levels were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.95%and 97.62%, respectively, and there were differences between two groups (P<0.05). The endometrial thickness, bleeding control time, and complete hemostasis time were lower than those in the treatment group with significantly differences (P<0.05). E₂, P, FSH, and PRL levels in two groups were decreased significantly (P<0.05). And those indexes in the treatment group decreased more significantly than those in the control group (P<0.05). Conclusion Gongbao Zhixue Granules combined with desogestrel ethinylestradiol has a significant clinical effect in treatment of dysfunctional uterine bleeding, and can significantly improve the clinical symptoms and sex hormone levels, which has a certain clinical application value.