Effect of experimental hyperprolactinemia on the sexual cycle and folliculogenesis

It is found that hyperprolactinemia results in the development of stable anovulation, in which the disruption of folliculogenesis sets in as early as at the stage of late preantral (graafian) follicles and manifests itself in a decrease of the mitotic activity in cells of the membrana granulosa. The concentration of follicle-stimulating hormone thereupon changes to different extents or remains at the control level. A direct influence of prolactin on intrafollicular estrogen production and on cell division is postulated. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 9, pp. 326–328, September, 1994