| 放射性~(125)I粒子治疗食管鳞癌的安全性及疗效 |
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| 引用本文： | 吕进,曹秀峰,朱斌,纪律,肖建,王冬冬,陶磊,王山,安红银. 放射性~(125)I粒子治疗食管鳞癌的安全性及疗效[J]. 世界华人消化杂志, 2010, 0(29) |
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| 作者姓名： | 吕进 曹秀峰 朱斌 纪律 肖建 王冬冬 陶磊 王山 安红银 |
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| 作者单位： | 南京医科大学附属南京第一医院肿瘤外科;复旦大学附属中山医院青浦分院;盐城市肿瘤医院胸外科; |
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| 摘 要： | 目的:探讨125I粒子在体内外对人ESCC的疗效和作用机制以及植入治疗胸段中晚期食管鳞癌(ESCC)的安全性及疗效.方法:细胞及动物实验:125I粒子植入体外培养的人食管鳞癌Eca-109细胞,分A组不加粒子(对照组);B组0.2mCi(低剂量组);C组0.4mCi(中剂量组);D组0.8mCi(高剂量组).分析细胞克隆形成率、细胞凋亡指数和细胞周期分布情况;建立裸鼠皮下移植性食管癌模型后,对照组(A组,不做任何处理)、假手术组(B组,穿刺瘤体1次,但不植入粒子)、低剂量组(C组,0.2mCi)、中剂量组(D组,0.4mCi)和高剂量组(E组,0.8mCi),计算各组抑瘤率.临床试验:前瞻性研究,入组时间为2000-2004年.根据ESCC术前CT分期标准,298例Ⅱ-Ⅲ期胸段ESCC患者随机分为术中联合125I粒子植入组及单纯手术组.依据TPS所确定的剂量,A组术中直视下植入125I粒子.选用0.5mCi的125I粒子20-40粒,总活度在10-30mCi,肿瘤匹配周边剂量60-70Gy,术后行粒子验证和质量评估.观察患者术后并发症、监测局部复发情况、评价患者疗效.结果:细胞克隆形成率B、C、D组均低于A组...
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| 关 键 词： | 食管鳞癌 近距离放射疗法 125I粒子 胸外科 |
~(125)I seed implantation brachytherapy for esophageal squamous cell carcinoma |
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| Jin Lv,Xiu-Feng Cao,Bin Zhu,Lv Ji,Dong-Dong Wang,Lei Tao. ~(125)I seed implantation brachytherapy for esophageal squamous cell carcinoma[J]. World Chinese Journal of Digestology, 2010, 0(29) |
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| Authors: | Jin Lv Xiu-Feng Cao Bin Zhu Lv Ji Dong-Dong Wang Lei Tao |
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| Affiliation: | Jin Lv,Xiu-Feng Cao,Bin Zhu,Lv Ji,Dong-Dong Wang,Lei Tao,Department of Oncological Surgery,Nanjing First Hospital Affiliated to Nanjing Medical University,Oncology Center of Nanjing Medical University,Nanjing 210006,Jiangsu Province,China Jian Xiao,Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University,Shanghai 201700,China Shan Wang,Hong-Ying An,Department of Thoracic Surgery,Yancheng Tumor Hospital,Yancheng 224002,China |
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| Abstract: | AIM:To evaluate the safety and efficacy of intraoperative 125I seed implantation for advanced esophageal squamous cell carcinoma(ESCC).METHODS:Eca-109 cells cultured in vitro were divided into four groups:cells untreated(control group) and those treated with low-(0.2 mCi),medium-(0.4 mCi) and high-dose 125I seeds(0.8 mCi).After 125I seed implantation,the cloning efficiency,apoptotic index and cell cycle of Eca-109 cells were detected.For animal experiment,Eca-109 cells were inoculated subcutaneously in the ... |
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| Keywords: | Esophageal squamous cell carcinoma Brachytherapy 125I seed Thoracic surgery |
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