骨髓间充质干细胞逆转肝纤维化的研究进展

骨髓间充质干细胞是一种来源于骨髓基质的具有多向分化能力的干细胞,在特定条件下,可以分化为骨细胞、软骨细胞、脂肪细胞、神经元样细胞及肝细胞等.近年研究表明,骨髓间充质干细胞能抑制和减轻肝纤维化,并且具有免疫抑制和诱导免疫耐受的作用.因此,在细胞移植治疗终末期肝病方面具有广阔的临床应用前景.

Advances in research of the reversal of liver f ibrosis by transplantation of bone marrow mesenchymal stem cells

Bone marrow mesenchymal stem cells(BMSCs) are a group of stem cells capable of multilineage differentiation.Under given conditions,BMSCs can differentiate into a variety of cells,such as osteoblasts,chondrocytes,adipocytes,neuronlike cells and hepatocytes.In recent years,numerous studies have shown that BMSCs can not only inhibit and reduce liver fibrosis but also induce immunosuppression and immune tolerance.Therefore,transplantation of BMSCs can be used to treat end-stage liver disease.