母亲患梅毒所产新生儿的临床资料分析

目的通过对母亲患梅毒所生产新生儿的临床资料进行分析，探讨母亲患梅毒时新生儿患先天性梅毒的发病及转归情况。方法对住院诊断为梅毒的40例产妇临床资料进行回顾性分析，监测新生儿出生后患先天性梅毒的发病情况、临床表现及转归。结果新生儿早期先天性梅毒发病9例，发生率为22．5％；临床特征及表现依次为：皮肤损害、长骨骨骼损坏、肝功能损害。余31例新生儿出生后立即行梅毒螺旋体明胶颗粒凝集试验（TPPA）、梅毒快速血浆反应（RPR），两项试验结果均为阳性，其中TPPA抗体滴度小于其母亲4倍，随诊12个月转阴；行x线及肝功等检查提示无多器官功能损害。结论母亲患梅毒所生新生儿先天性梅毒发生率较高，早期治疗效果好；应对母亲患梅毒所生产未患先天性梅毒的新生儿严格随诊。实验室指标监测至少1年。

Clinical analysis of neonates delivered by women with syphilis

Objective To investigate the incidence of syphilis and its outcomes of neonates delivered by women with syphilis through analyzing the clinical data of the neonates. Methods Retrospective analysis was conducted on the clinical data of 40 cases of maternal syphilis diagnosed in hospital, and the incidence of congenital syphilis （CS） , clinical manifestations and outcomes of neonates were monitored. Results Neonatal CS was detected in 9 cases, and the morbidity was 22.5%. Its clinical features and manifestations included skin damage, bone damage and liver damage. The rest 31 cases accepted treponemal pallidum particle agglutination （TPPA） and syphilis rapid plasma reaction （RPR） immediately after birth, and the results were positive. The TPPA titer of neonates was 4 times less than their mothers＇, and the test became negative after follow-up for 12 months. X-ray and liver function examination showed no damage in organs. Conclusion Morbidity of neonatal CS is relatively high and early treatment can achieve good effect. Being the neonates of mothers who suffering from syphilis, neonates without CS should be followed strictly and their laboratory indexes should be monitored for at least 12 months.