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人肠道病毒71型感染致重症手足口病的危险因素分析
引用本文:庄帝钱,梁翠琼,赵芳,谢宏发. 人肠道病毒71型感染致重症手足口病的危险因素分析[J]. 中国热带医学, 2019, 19(4): 373-376. DOI: 10.13604/j.cnki.46-1064/r.2019.04.17
作者姓名:庄帝钱  梁翠琼  赵芳  谢宏发
作者单位:深圳市龙华区中心医院儿科,广东 深圳 518110
基金项目:深圳市科技计划知识创新类基础研究项目(No.JCYJ20150402140827345)
摘    要:
目的 探讨肠道病毒71型感染导致重症手足口病的危险因素。方法 选取2015年5月至2017年10月间我院感染科收治的EV71型手足口病患儿140例为研究对象,依据临床分期标准分为普通病例组95例和重症病例组45例,收集并比较两组患儿一般资料、临床表现、实验室指标等,采用多因素Logistics回归分析判断影响手足口病重症化的危险因素。结果 两组患儿的性别、年龄、BMI间比较差异无统计学意义(P>0.05);两组患儿的ALT、AST、脑脊液葡萄糖浓度比较差异无统计学意义(P>0.05),但重症病例组的WBC [(12.65±3.51)×109/L vs (9.16±3.44)×109/L]、CRP[(10.67±4.75)mg/L vs(6.58±3.04) mg/L]、热程[(7.46±2.21)d vs(2.93±1.22)d]、热峰[(38.91±0.35) ℃ vs(38.34±0.45) ℃]、血糖[(8.40±0.78) mmol/L vs(5.96±1.14) mmol/L]、CK-MB[(17.84±1.57)U/L vs(15.75±1.64)U/L]、NP[53.47(31.50~70.22)% vs 46.89(29.44~67.01)%]、肢体抖动(37.78% vs 9.47%)、脑脊液蛋白质浓度[319.63(211.40~463.53)mg/L vs 224.82(172.24~396.91)mg/L]、脑脊液细胞数[(18.74±5.62)×106/L vs (4.87±2.03)×106/L]均较普通病例组显著升高,脑脊液氯化物水平[(117.52±2.84)mmol/L vs (119.75±3.09)mmol/L]较普通病例组显著降低,差异有统计学意义(P<0.05);多因素Logistics回归分析发现,热程延长(OR=8.812)、热峰升高(OR=682.359)、血清CRP(OR=1.920)、CK-MB水平升高(OR=6.299)以及脑脊液蛋白质浓度升高(OR=1.014)是手足口病重症化的独立危险因素(P<0.05)。结论 EV71感染手足口病重症化与患儿年龄、性别无关,与热程、热峰、CRP、CK-MB、脑脊液蛋白质浓度呈正相关,可作为判断EV71感染手足口病重症化的独立危险因素。

关 键 词:重症手足口病  肠道病毒71  危险因素  
收稿时间:2018-06-28

Risk factors for severe hand foot mouth disease caused by enterovirus 71 infection
ZHUANG Diqian,LIANG Cuiqiong,ZHAO Fang,XIE Hongfa. Risk factors for severe hand foot mouth disease caused by enterovirus 71 infection[J]. China Tropical Medicine, 2019, 19(4): 373-376. DOI: 10.13604/j.cnki.46-1064/r.2019.04.17
Authors:ZHUANG Diqian  LIANG Cuiqiong  ZHAO Fang  XIE Hongfa
Affiliation:Department of Pediatrics, Longhua District Central Hospital, Shenzhen, Guangdong 518110, China
Abstract:
Objective To investigate the risk factors of severe hand foot mouth disease (HFMD) caused by enterovirus 71 infection. Methods A total of 140 children with EV71 type hand foot and mouth disease in the Department of Infection in our hospital from May 2015 to October 2017 were selected as the research object, and divided into the general case group and the severe case group according to the clinical stage standard. The children's general data, clinical manifestations and laboratory indexes in the two groups were collected and compared. Multivariate logistics regression analysis was used to determine the risk factors for severe hand foot mouth disease. Results There was no significant difference in gender, age and BMI between the two groups (P>0.05). There was no significant difference in the ALT, AST and glucose concentration of CSF in the two groups (P>0.05), but the WBC [(12.65±3.51) ×109/L vs (9.16±3.44)×109/L], CRP [(10.67±4.75) mg/L vs (6.58±3.04) mg/L], fever time[(7.46±2.21) d vs (2.93±1.22) d], hot peak (38.91±0.35)℃ vs (38.34±0.45)℃], blood glucose[(8.40±0.78) mmol/L vs (5.96±1.14) mmol/L], CK-MB [(17.84±1.57) U/L vs (15.75±1.64) U/L], NP [53.47 (31.50-70.22)% vs 46.89 (29.44-67.01)%], limb shaking (37.78% vs 9.47%), cerebrospinal fluid protein concentration [319.63 (211.40-463.53)mg/L vs 224.82(172.24-396.91) mg/L] and cerebrospinal fluid cell number [(18.74±5.62)×106/L vs (4.87±2.03)×106/L] in the severe case group were significantly higher than those of the general case group, and the level of chlorides[(117.52±2.84) mmol/L vs(119.75±3.09) mmol/L] in cerebrospinal fluid was significantly lower than that of the common case group (P<0.05). The multiple factor logistics regression analysis showed that the prolonged fever time (OR=8.812), the increase of hot peak(OR=682.359), the increase of serum CRP (OR=1.920), CK-MB (OR=6.299) and the increase of the concentration of cerebrospinal fluid protein (OR=1.014) were independent risk factors for the severe hand foot and mouth disease (P<0.05). Conclusions The severity of EV71 type hand foot and mouth disease is not related to the age and sex of the children. It has a positive correlation with the fever time, hot peak, CRP, CK-MB, and the protein concentration of cerebrospinal fluid, which can be used as independent risk factors to judgethe severity of EV71 type hand foot and mouth disease.
Keywords:severe hand foot mouth disease  enterovirus 71  risk factors  
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