| 瞬时感受器电位香草酸受体1在糖尿病神经病理性痛大鼠背根神经节中的表达 |
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| 引用本文： | 许先成,叶宝霞,王家红,柯昌斌. 瞬时感受器电位香草酸受体1在糖尿病神经病理性痛大鼠背根神经节中的表达[J]. 郧阳医学院学报, 2010, 29(5) |
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| 作者姓名： | 许先成 叶宝霞 王家红 柯昌斌 |
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| 作者单位： | 许先成,柯昌斌,XU Xian-cheng,KE Chang-bin(湖北医药学院附属太和医院麻醉科,湖北,十堰,442000);叶宝霞,YE Bao-xia(湖北医药学院附属太和医院护理部,湖北,十堰,442000);王家红,WANG Jia-hong(房县中医院麻醉科,湖北,房县,442100) |
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| 摘 要： | 目的:探讨瞬时感受器电位香草酸受体1(TRPV1)在糖尿病大鼠神经病理性疼痛形成中的作用。方法:64只Wistar大鼠腹腔注射链脲菌素制备糖尿病模型,随机分为糖尿病神经病理性疼痛组(D组)和TRPV1抑制剂组(E组),E组大鼠腹腔再注射TRPV1拮抗剂SB366791。分别于第2、4、6、8周末测定每组大鼠机械缩足反应阈值(MWT)、左侧坐骨神经传导速度(NCV)、背根神经节(DRG)中TRPV1表达情况。另取32只大鼠做空白对照组(C组)。结果:随糖尿病时间延长,D组MWT和NCV值逐渐降低,TRPV1水平逐渐升高(P<0.05);E组MWT和NCV值逐渐增高,TRPV1水平逐渐降低(P<0.05)。结论:糖尿病大鼠神经病理性疼痛的形成和维持与大鼠背根神经节中TRPV1表达水平上调有关。
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| 关 键 词： | 瞬时感受器电位香草酸受体1 糖尿病神经病变 疼痛 |
The Expression of Transient Receptor Potential Vanilloid 1 in Dorsal Root Ganglion of Rats with Diabetic Neuropathic Pain |
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| XU Xian-cheng,YE Bao-xia,WANG Jia-hong,KE Chang-bin. The Expression of Transient Receptor Potential Vanilloid 1 in Dorsal Root Ganglion of Rats with Diabetic Neuropathic Pain[J]. Journal of Yunyang Medical College, 2010, 29(5) |
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| Authors: | XU Xian-cheng YE Bao-xia WANG Jia-hong KE Chang-bin |
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| Affiliation: | 1(1Department of Anesthesiology; 2Department of Nursing; Taihe Hospital; Hubei University of Medicine; Shiyan; Hubei 442000; 2Fangxian Traditional Chinese Medical Hospital; Fangxian; Hubei 441200; China); |
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| Abstract: | Objective To investigate the role of transient receptor potential vanilloid 1(TRPV1) in the pathogenesis of rats with diabetes neuropathic pain induced by streptozocin.Methods Sixty-four Wistar rats were induced with streptozocin intraperitoneal injection and then randomly divided into diabetic neuropathic pain group(group D) and TRPV1 inhibited group(group E).SB 366791,an antagonist of TRPV1 was given with intraperitoneal injection in group E additionally.Another 32 Wistar rats were selected as control gro... |
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| Keywords: | Transient receptor potential vanilloid 1 Diabetic neuropathy Pain |
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