| 老年前期雌性大鼠下丘脑-垂体-卵巢轴的功能变化 |
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| 引用本文： | 廖柏松,鞠躬,张伯讷. 老年前期雌性大鼠下丘脑-垂体-卵巢轴的功能变化[J]. 医学争鸣, 1997, 0(6) |
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| 作者姓名： | 廖柏松 鞠躬 张伯讷 |
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| 作者单位： | 第四军医大学神经科学研究所!西安，710033，第四军医大学神经科学研究所!西安，710033，上海中医药大学分子生物学研究室 |
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| 基金项目： | 上海市教委科学技术发展基金 |
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| 摘 要： | 研究雌性老年前期大鼠性腺轴功能的变化．方法：应用阴道细胞形态学检查法和放射免疫测定法观察18月龄雌性SD大鼠动情周期和组织中性激素含量的变化．结果：18月龄雌性大鼠血清E2水平降低，LH和FSH含量升高；下丘脑和血浆GnRH水平上升，垂体GnRH含量减少．结论：18月龄雌性老年前期SD大鼠动情周期停止，下匠脑－垂体－卵巢轴功能明显衰退．
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| 关 键 词： | 大鼠 性腺轴 衰老 |
Alterations of the hypothalamic-pituitary-ovarian axis function in 18 month old female rats |
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| Liao Baisong,Ju Gong,Zhang Bona. Alterations of the hypothalamic-pituitary-ovarian axis function in 18 month old female rats[J]. Negative, 1997, 0(6) |
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| Authors: | Liao Baisong Ju Gong Zhang Bona |
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| Abstract: | To study the aging changes of the hypothalamic-pituitary-ovarian axis function in 18 month old female rats. Methods: Radioimmunoassay and histochemistry methods. Results: The serum E2 levels and pituitary GnRH levels in the aged rats were lower than that of young rats. The levels of LH, FSH in serum and GnRH in the hypothalamus and plasma in the 18 month old female rats were higher than than of of the control.Conclusion: The dysfunction and aging of the reproductive axis were observed in 18 month old female rats. |
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| Keywords: | female rats reproductive axis aging |
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