| 黄药子的化学成分研究 |
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| 引用本文： | 邱军强,李春峰,苗晶囡,张翀,包顺茹,刘树民,陈平平.黄药子的化学成分研究[J].中医药学报,2013(5):14-16. |
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| 作者姓名： | 邱军强 李春峰 苗晶囡 张翀 包顺茹 刘树民 陈平平 |
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| 作者单位： | [1]黑龙江中医药大学中医药研究院,黑龙江哈尔滨150040 [2]哈尔滨医科大学附属第三医院胃肠外科,黑龙江哈尔滨150040 |
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| 基金项目： | 国家自然科学基金资助项目（No.30572368）;黑龙江省卫生厅科研项目（No.2011-145）. |
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| 摘 要： | 目的：对薯蓣科植物黄药子（Dioscorea bulbiferaL.）块茎进行化学成分研究.方法：95％乙醇提取物经系统溶剂萃取后,得到的氯仿萃取部分,应用硅胶柱色谱、高效液相色谱和重结晶等方法进行分离纯化,通过波谱解析进行结构鉴定.结果：从中分离得到5个化合物,根据理化性质和谱学分析鉴定为黄独乙素（diosbulbin-B,Ⅰ）,β-扶桑甾醇（β-msasterol,Ⅱ）,β-谷甾醇（β-sitosterol,Ⅲ）,（S）5乙基-8,8-二甲基壬醛（《S）-5-Ethyl-8,8-dimethyl nonanal,Ⅳ）,2,3-Dihydroxyicosanoic酸（2,3-Dihydroxyicosanoic acid,Ⅴ）.结论：化合物（Ⅱ）、（Ⅳ）、（Ⅴ）为首次从黄药子中分离得到的已知化合物.
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| 关 键 词： | 中药 黄药子 化学成分 甾醇 薯蓣属 |
Research of Chemical Composition of Dioscorea bulbifera L. |
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| Institution: | QIU Jun-qiang(Academy of Traditional Chinese Medicine of Heilongjiang University of Chinese Medicine Harbin 150040, China) LI Chun-feng(The Third Affiliated Hospital of Harbin Medical University Gastrointestinal Surgery,Harbin 50040 China) MIAO Jing-nan(Academy of Traditional Chinese Medicine of Heilongjiang University of Chinese Medicine Harbin 150040, China) ZHANG Chong(Academy of Traditional Chinese Medicine of Heilongjiang University of Chinese Medicine Harbin 150040, China) BAO Shun-ru(Academy of Traditional Chinese Medicine of Heilongjiang University of Chinese Medicine Harbin 150040, China) LIU Shu-min(Academy of Traditional Chinese Medicine of Heilongjiang University of Chinese Medicine Harbin 150040, China) |
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| Abstract: | Objective：To study the chemical constituents of the rhizome of Dioscorea bulbifera L..Methods：Five compounds were isolated and purified by chromatographic column of silica gel,recrystallization and other methods.Their structures were identified by spectral analysis.Results：Five compounds were isolated from the chloroform extraction parts of Dioscorea bulbifera L.,which were diosbulbin-B（Ⅰ）,β-rosasterol（Ⅱ）,β-sitosterol（Ⅲ）,（S）-5-Ethyl-8,8-dimethyl nonanal（Ⅳ）.Conclusion：Compounds（Ⅱ）,（Ⅳ）,（Ⅴ） are found for the first time in Dioscorea plant. |
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| Keywords: | Traditional Chinese medicine dioscorea bulbifera L Chemical composition Sterol Dioscorea |
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