Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis |
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| Authors: | Mario A. Tan Hiromitsu Takayama Norio Aimi Mariko Kitajima Scott G. Franzblau Maribel G. Nonato |
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| Affiliation: | 1.Research Center for the Natural Sciences, Graduate School and College of Science,University of Santo Tomas,Manila,Philippines;2.Graduate School of Pharmaceutical Sciences,Chiba University,Chiba,Japan;3.Institute for Tuberculosis Research, College of Pharmacy,University of Illinois at Chicago,Chicago,USA |
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| Abstract: | Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5β-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and β-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H37Rv with a MIC of 64 μg/mL, while squalene and the sterol mixture have MICs of 100 and 128 μg/mL, respectively. |
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| Keywords: | Pandanus Pandanus tectorius Soland. var. laevis Tirucallane Mycobacterium tuberculosis |
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