人胎胸腺皮髓质体积发育的形态定量学研究

目的　探讨人胎胸腺皮髓质体积发育的规律。方法　应用体视学原理和统计学方法 ,对 79例胎龄 13～ 4 1周的正常人胎胸腺皮髓质体积进行形态定量研究。结果　在人胎胸腺发育过程中 ,皮质体积密度、髓质体积密度及皮、髓质体积比均较稳定 ,不同胎龄间无显著差异。 95 %正常值范围 (mm0 )分别为 :0 .6 39± 0 .14 1、0 .2 4 3± 0 .12 2及 2 .86 7± 2 .0 39;95 %可信限 (mm0 ) :0 .6 39± 0 .0 16、0 .2 4 3± 0 .0 14及 2 .86 7± 0 .2 13。皮质体积密度显著大于髓质 ,皮、髓质体积密度间呈负相关。结论　在正常人胎胸腺发育中 ,胸腺皮、髓质体积的发育与胸腺体积的发育保持平衡。胸腺皮、髓质体积密度与皮、髓质体积比都可以更好地代表人胎胸腺的正常状态

A morphometric study of thymus cortex medulla volume in human fetus

Objective To explore the developmental regular pattern of thymus cortex and medulla volume in human fetus.Methods 79 normal human thymus taken in fetuses from 13th to 41th gestational weeks were studied quantitatively with stereologic method and analyzed statistically.Results During the period of development, the cortex volume density, the medulla volume density and the volume ratio of cortex to medulla were stable. The variations of each of the above parameters of thymus in different gestational months showed no significant differences.95% normal ranges(mm 0)of the cortex volume density, the medulla volume density and the volume ratio of cortex to medulla were 0.639±0.141,0.243±0.122 and 2.867±2.039 and their 95% confidence limits(mm 0)were 0.639±0.016,0.243±0.014 and 2.867±0.213, respectively. The cortex volume density was larger than that of medulla. The volume density of cortex was correlated with that of the medulla negatively.Conclusion In normal thymus development of human fetus ,volume of thymus and the volume of thymus cortex and thymus medulla are well in balance. The cortex volume density, the medulla volume density and the volume ratio of cortex to medulla might represent the normal state of human fetus thymus.