不同剂量盐酸纳络酮治疗急性脑梗死的临床观察

目的观察应用不同剂量的盐酸纳络酮治疗急性脑梗死的临床疗效及安全性。方法将180例急性脑梗死患者随机分为对照组、纳络酮治疗A组(6～8mg/d)和纳络酮治疗B组(2mg/d),疗程15天;治疗前后分别行神经功能缺损评分,疗程结束后行临床疗效评定,并观察药物副作用。结果纳络酮治疗A组和B组神经功能缺损的改善均优于对照组,尤以治疗A组明显(P<0.01),而且无明显副作用;临床疗效均优于对照组。结论早期大剂量应用纳络酮治疗急性脑梗死,临床疗效好,安全性高。

Clinical research of naloxone of different dosages in the treatment of acute cerebral infarction.

Objective To assess the clinical effects and the safety of naloxone in the treatment of acute cerebral infarction. Methods 180 patients with acute cerebral infarction were randomly divided into three groups: Control Group, naloxone treated group A (6~8 mg/d) and naloxone treated group B (2 mg/d). 60 patients were included for each group. All patients were investigated by using Chinese scale of clinical neurologic deficit before and after treatment, respectively. Clinical effects and drug sige effect were evaluated after treatment. Results Neural dysfunction improved significentig in the naloxone treatment groups, especially in nalonone treated group A (P<0.01), and no obviously drug side effects were observed. Conclusion The early usage of large dose of naloxone is effective and safe in the treatment of acute cerebral infarction.