| 脑梗塞患者血浆抗凝血酶、血管性血友病因子和D二聚体测定的临床意义 |
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| 引用本文： | 吉薇,顾健,沈连军,马莉,吴蔚,倪军,王红,方悦之. 脑梗塞患者血浆抗凝血酶、血管性血友病因子和D二聚体测定的临床意义[J]. 血栓与止血学, 2013, 19(4): 167-168 |
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| 作者姓名： | 吉薇 顾健 沈连军 马莉 吴蔚 倪军 王红 方悦之 |
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| 作者单位： | 江苏省苏北人民医院,血液学研究所实验室,扬州,225001 |
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| 摘 要： | 目的观察急性脑梗塞患者的血浆抗凝血酶（AT）、血管性血友病因子（vWF）和D二聚体（D-D）的含量，探讨其与脑梗塞的关系。方法检测急性期发病时的50例脑梗塞患者血浆AT、vWF和D-D的含量。结果脑梗塞患者D-D、vWF表达水平分别为1．19±1．56μg/ml、174．01±33．37％明显高于正常对照组的0．31±0．15μg／ml、116．40±20．74％（P〈0．01），AT的含量（80．42±26．27％）低于对照组（101．78±11．56％）（P〈0．01）。结论这些指标可以有助于判断脑梗塞患者血管内皮细胞功能受损以及纤溶系统激活的情况，对脑梗塞患者早期诊断和治疗具有指导性意义。
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| 关 键 词： | 脑梗塞 抗凝血酶 血管性血友病因子 D二聚体 |
The Clinical Significance of Plasma Antithrombin, von Willebrand Factor and the D-Dimer Assay in Cerebral Infarction Patients |
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| Affiliation: | JI Wei, GU Jian , CHEN Lian-jun, MA Li, WU Wei, NI Jun, WANG Hong, FANG Yue- zhi ( Jiangsu Subei People＇ s Hospital, Institute of Hematology Laboratory, Yangzhou ,225001, China.) |
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| Abstract: | Objective To investigate the content and relationship of antithrombin （AT）, yon Wille- brand factor（vWF） and D-dimer（D-D） of the plasma of patients with acute cerebral infarction. Methods Detection the content of AT ,vWF and D-D of the plasma of 50 patients with acute cerebral infarction. Results The content of AT and vWF of patients with acute cerebral infarction were higher than those in normal con- trol（ P 〈0.01 ）, and the content of D-D werelower than those in normal control（ P 〈 0.01 ）. Conclusion These indicators could help derermining the vascular endothelial cell dysfunction and activation of the fibrion- lyric system of patients with cerebral infarction, and guiding the early diagnosis of patients with cerebral infarc- tion. |
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| Keywords: | Acute cerebral infarction Antithrombin von Willebrand Factor D-Dimer |
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