Hepatitis B and the Immune System |
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Authors: | Kyong-Mi Chang |
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Institution: | 1.Division of Gastroenterology, Department of Medicine,Philadelphia VA Medical Center and University of Pennsylvania,Philadelphia,USA |
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Abstract: | As a persistent virus, hepatitis B virus (HBV) is believed to be noncytopathic in most circumstances, with its disease pathogenesis
mediated by host innate and adaptive immune responses. Although HBV may initially avoid activating critical innate intracellular
defenses (eg, type I interferons), T cells exert both cytopathic and noncytopathic antiviral effects toward resolution of
HBV infection. With chronic HBV infection, various immune regulatory or tolerance mechanisms are induced with varying degrees
of effector T-cell dysfunction and liver inflammation, which contributes to liver disease progression. This review highlights
some components of host immune response relevant for HBV infection, including the more recent appreciation of immune regulatory
mechanisms induced during chronic viral infection. Although therapeutic options are evolving for HBV, a better understanding
of its immune pathogenetic and regulatory mechanisms may help develop better approaches to treat HBV infection and prevent
disease progression. |
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