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| SKP2及MRP-1/CD9在声门癌及癌旁组织中的表达及其临床意义 | |
| 引用本文： | 王艳,孙彦,孙文海,陈志俊,安丰苗. SKP2及MRP-1/CD9在声门癌及癌旁组织中的表达及其临床意义[J]. 临床耳鼻咽喉头颈外科杂志, 2010, 24(4) |
| 作者姓名： | 王艳 孙彦 孙文海 陈志俊 安丰苗 |
| 作者单位： | 青岛大学附属医院耳鼻咽喉科,山东青岛,266003 |
| 摘 要： | 目的:观察声门癌及癌旁组织中SKP2及MRP-1/CD9蛋白的变化意义及其对声门癌手术安全切除范围的指导意义。方法:用免疫组织化学SP法检测38例声门鳞状细胞癌组织及距癌组织边缘2、5、10mm的组织中SKP2及MRP-1/CD9蛋白的表达,并取10例声带息肉组织作对照。结果:SKP2蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10mm)及癌组织的顺序依次递减,差异有统计学意义(均P<0.05);MRP-1/CD9蛋白产物异常表达按息肉黏膜组织、癌旁组织(2、5、10mm)及癌组织的顺序依次递增,差异有统计学意义(均P<0.05)。结论:SKP2及MRP-1/CD9均可作为判断喉癌生物学特性的参考指标,声门癌手术安全切缘以距肿瘤≥5mm的标准较为适宜。 |
| 关 键 词： | 声门肿瘤 SKP2 MRP-1/CD9 免疫组织化学 安全切缘 |
Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues |
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| WANG Yan,SUN Yan,SUN Wenhai,CHEN Zhijun,AN Fengmiao. Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues[J]. Journal of clinical otorhinolaryngology, head, and neck surgery, 2010, 24(4) | |
| Authors: | WANG Yan SUN Yan SUN Wenhai CHEN Zhijun AN Fengmiao |
| Affiliation: | Department of Otorhinolaryngology/a>;the Affiliated Hospital of Medical College of Qingdao University/a>;Qingdao/a>;266003/a>;China |
| Abstract: | Objective:To study the expression of SKP2 and MRP-1/CD9 protein in glottic cancer and adjacent tissues,and to analyze its significance for a safe surgical margin.Method:Thirty-eight cases of glottic squamous cell carcinoma were studied for its cancer tissue,tissue 2 mm,5 mm ,and 10 mm away from cancer ,and 10 cases of vocal cord polyp were served as control. SKP2 and MRP-1/CD9 protein were examined by immunoh istochemical method.Result:The positive expression of SKP2 proteins decreased in sequence of polyp ... |
| Keywords: | glottic neoplasms SKP2 MRP-1/CD9 immunohistochemistry safe resection margin |
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