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上皮-间质转化在非小细胞肺癌侵袭与转移中作用的研究进展
引用本文:贺金奇[综述] 王晓红[审校]. 上皮-间质转化在非小细胞肺癌侵袭与转移中作用的研究进展[J]. 实用肿瘤学杂志, 2013, 0(6): 559-562
作者姓名:贺金奇[综述] 王晓红[审校]
作者单位:哈尔滨医科大学附属肿瘤医院内五科,哈尔滨150081
摘    要:上皮-间质转化(Epithelial—mesenchymal transition,EMT)与恶性肿瘤的侵袭及转移有着密切的关系,是目前研究恶性肿瘤侵袭及转移的热点。有大量研究表明在多种恶性肿瘤如乳腺癌、卵巢癌和非小细胞肺癌的侵袭与转移过程中都有上皮-间质转化现象,并阐述上皮-间质转化的信号通路及其蛋白分子。本文对上皮-间质转化在非小细胞肺癌侵袭与转移的研究成果做一综述。

关 键 词:非小细胞肺癌  侵袭与转移  上皮-间质转化

Research progress of epithelial - mesenchymal transition in Non - small cell lung cancer invasion and metastasis
Affiliation:HE Jinqi, WANG Xiaohong Department of Respiratory Oncology, The Affiliated Tumor Hospital of Harbin Medical University, Harbin 150081, China
Abstract:Epithelial - mesenchymal transition is closely related with invasion and metastasis of malig- nant tumor and is focused on invasion and metastasis in malignant tumor in recent years. Many researches dermon- strate that epithelial - mesenchymal transition is involved in invasion and metastasis of several malignant tumors, such as breast cancer, ovary cancer and non - small cell lung cancer. The relevant signal pathways and molecular proteins are also studied. Research progress of epithelial - mesenchymal transition in non - small cell lung cancer for invasion and metastasis is reviewed in this article.
Keywords:Non- small cell lung cancer  Invasion and metastasis  Epithelial- mesenchymal transition
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