新生儿先天性畸形与孕妇乙型肝炎病毒感染关系的研究

为探讨孕妇乙型肝炎病毒(HBV)感染和某些因素对先天性畸形的致病作用,本文进行了96对新生儿先天畸形的配对(1:1)病例对照研究,报道先天畸形的频率和构成,单因素和多因素的条件Logistic回归分析,表明孕妇HBsAg阳性等6个因素对先天畸形呈阴性结果,而与接触农药和孕周的因素有明显联系,值得进一步探讨。

The Relationship Between Congenital Malformation of Newborn and Hepatitis B Virus Infection of Pregnant Women

In order to investigate the adverse effect of HBV infection as well as some risk factors from pregnant women on the congenital malformation of newborn, a case-control study on congenital malformation with 96 matched pairs was carried out in Guangzhou. The frequencies and component percentages of congenital malformation were reported and the monofactorial and multifactorial analyses were fitted by using Conditional Logistic Regression model. The results showed that those pregnant women with positive HBsAg did not have anything to do with the development of congenital malformation, however, those with insecticide exposure and shorter pregnant duration were the risk factors worthy for further study.