贵州民族药飞蛾七的药效学实验研究

目的评价贵州民族药飞蛾七的抗菌、抗炎、解热作用和安全性。方法采用小鼠耳壳肿胀法、小鼠腹腔致炎法、大鼠2,4二硝基苯酚致热法、体外抗菌法、小鼠体内急性毒理实验。结果飞蛾七能够明显抑制二甲苯所致小鼠耳壳炎性肿胀、降低二甲苯所致小鼠皮肤毛细血管通透性,同时,具有对2,4二硝基苯酚所致大鼠体温升高有较好的解热作用。另外还发现飞蛾七对体外大肠杆菌、绿脓杆菌,对小鼠体内感染大肠杆菌有良好的抗菌作用,急性毒性小。结论飞蛾七具有较好的解热、抗炎作用,使用安全。

Experimental study on pharmacodynamical of Oxalis griffithii,an national medicine in Guizhou

Objective: To study the on effects of anti-bacteria, anti-inflammatory and pyretolysis of Oxalis griffithii,it is possible safety. Method: The mice model was established by xylene (auricle smear method) and carrageenin(injection under the aponeuroses) respectively,rat febrile model was builded by 2,4-dintrophenol injection. and observe the effects of anti-bacteria in vitro that contracted by staph aureus, escherichia, shigella, pseudomonas, aeruginosa. The mice model of experiment study on urgent poison effects(injection under the aponeuroses). Result: It was found that the mouse'ear edema induced by xylene, the increased vascular permeability caused by xylene were all significantly suppressed by Oxalis griffithii. At the same time, it could depressed the rat fervescence by 2, 4-dnitrophenol. In addition, It has effect on fighting against escherichia coli in cavum abdominis of mice. Oxalis griffithii hasn't canker affect. Conclusion: These results suggested that Oxalis griffithii had the effects of antinflammatory, pyuetolysis, and safety.