补肾调冲方在多囊卵巢综合征中的辅助治疗作用及机制研究

目的 探讨补肾调冲方治疗多囊卵巢综合征（PCOS）的临床疗效对氧化应激的影响。方法 选取我院2016年1月-2018年12月符合PCOS诊断标准的病例100例，以随机数表法随机分为观察组和对照组，每组50例。对照组采取达英-35+来曲唑组进行治疗，观察组在对照组治疗方案的基础上同时给于补肾调冲方治疗，总疗程为6个月经周期，记录两组患者临床资料，检测治疗前后患者脂肪细胞因子、性激素、氧化应激等指标。结果 治疗后，观察组内脂素（visfatin，VF）、瘦素（leptin，LEP）、体质量指数（body mass index，BMI）、腰臀比（waist-to-hip ratio, WHR），睾酮（testosterone，T）、促黄体生成激素（luteotropic hormone，LH）、卵泡刺激素（follicle-stimulating，FSH）、LH/FSH，丙二醛（malondialdehyde ，MDA）水平以及流产率显著低于对照组；脂联素（adiponectin，APN）水平，雌二醇（estradiol，E2）水平，超氧化物歧化酶（superoxide dismutase，SOD）、谷胱甘肽过氧化物酶（Glutathione peroxidase，GSH）水平，排卵率及妊娠率水平显著高于对照组（P<0.05），差异有统计学意义。结论 补肾调冲方对PCOS有较好的治疗作用，可减轻患者体质量，有效调节性激素水平，其机制可能与其改善氧化应激状态，缓解胰岛素抵抗有关。

Research on Adjunctive Therapeutic Effects and Mechanism of Bushen Tiaochong Decoction in Polycystic Ovary Syndrome

Objective To investigate clinical efficacy of Bushen Tiao Chong Decoction in treating Polycystic Ovary Syndrome and eEffect on oxidative stress.Methods 100 PCOS cases conforming diagnostic criteria from January 2016 to December 2018 in our hospital were randomly divided into observation group and control group by the random number table, 50 cases in each group. Patients in the control group was treated with ethinylestradiol cyproterone combined with letrozole group; on the basis, patients in the observation group was given the treatment of Bushen Tiaochong Decoction on the basis of the treatment plan of the control group. The total course of treatment was 6 menstrual cycles. Then the clinical data of the two groups were recorded, and the fat cytokines,sex hormones, oxidative stress and other indicators were measured before and after treatment. Results After treatment, the visfatin (VF), leptin (LEP), body mass index (BMI),waist-to-hip ratio (WHR), testosterone (T),luteotropic hormone (LH), follicle-stimulating (FSH), LH/FSH, malondialdehyde (MDA) levels and abortion rate the in observation group were significantly lower than those of the control group; adiponectin (APN) levels, estradiol (E2) levels, superoxide dismutase (SOD), glutathione peroxidase (GSH) levels, ovulation rate and pregnancy rate were significantly higher than those of the control group (P<0.05), and the difference was statistically significant. Conclusion Bushen Tiaochong Decoction has a good therapeutic effect on PCOS, which can reduce the body weight of patients, and regulate the level of sex hormones effectively. Its mechanism may be related to improving oxidative stress and alleviating insulin resistance.