Characterization of the anemia associated with chronic renal insufficiency |
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| Authors: | LOGE J P LANGE R D MOORE C V |
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| Affiliation: | 1. St. Louis, Missouri, USA;2. U.S. Public Health Service Research Fellow St. Louis, Missouri, USA;1. Department of Research, Cizik School of Nursing, The University of Texas Health Science Center at Houston, Houston, TX, USA;2. Department of Orthopedic Surgery, School of Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA;3. Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA;4. Department of Engineering Technology, University of Houston, Houston, TX, USA;1. Département d′Urologie, Transplantation Rénale et Andrologie, CHU Rangueil, TSA50032, 31059 Toulouse, France;2. Service d′Urologie, CHU de Rennes, Rennes, France;3. Service d′Urologie, CHU de Rouen, Rouen, France;1. Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China;2. Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, TX, USA;1. Department of Preventive Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea;2. Clinical Trial Center, Mokdong Hospital, Ewha Womans University, Seoul, Republic of Korea;3. Department of Food & Nutrition, Research Center for Human Ecology, College of Human Ecology, Kyung Hee University, Seoul, Republic of Korea;4. Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea;5. Department of Occupational and Environmental Medicine, School of Medicine, Ewha Womans University, Seoul, Republic of Korea;1. Institute of Disease Prevention and Control, Chinese People''s Liberation Army, Beijing 100071, China;2. Institute of Health and Environmental Medicine, Academy Military Medical Sciences, Tianjin 300050, China |
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| Abstract: | ![]()
The anemia occurring with chronic renal insufficiency was studied in twenty-six patients. From this study it is possible to draw the following conclusions: - 1.1. The anemia is usually normocytic and normochromic although an occasional patient has a consistently macrocytic mean corpuscular volume.
- 2.2. Serum iron and free erythrocyte protoporphyrin values follow no consistent pattern.
- 3.3. There is an invariable depression of erythropoiesis, demonstrated in these patients by poor utilization of radioiron. This constitutes the prominent mechanism responsible for the anemia.
- 4.4. Erythrocytes formed under conditions of severe renal insufficiency and azotemia are normal as measured by their ability to survive normally in healthy recipients.
- 5.5. Occasionally the anemia becomes rapidly progressive in the absence of detectible blood loss. At these times an unidentified extracorpuscular hemolytic factor is present and presumably is responsible for the increased breakdown of red cells. Thus the anemia must at times be due to a combined disorder of depressed erythropoiesis and increased red cell destruction.
- 6.6. Blood loss infrequently accounts for a significant part of the anemia, but in individual cases may be a third responsible factor.
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