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HLA-DRB1*01 and DRB1*04 alleles in Sardinian rheumatoid arthritis patients
Authors:Carcassi C  Passiu G  Lai S  Sanna G  Cauli A  Alba F  Mathieu A  Contu L
Affiliation:Cattedra di Genetica Medica, Dipartimento di Scienze Mediche, Universitàdi Cagliari, Italy;, Cattedra di Reumatologia II, Dipartimento di Scienze Mediche, Universitàdi Cagliari, Italy
Abstract:In Sardinia, like in other Caucasoid populations, rheumatoid arthritis (RA) is significantly associated with HLA-DR4 and DR1 antigens. To discover which DR4 and DR1 alleles were associated with the disease we selected 22 Sardinian patients affected by RA. Fifty DR4+ and 28 DR1+ healthy individuals coming from the same geographical area were used as controls. In the Sardinian patients only two DRB1*04 alleles were observed: DRB1*0405 in 11 and DRB1*0403 in three patients. The DRB1*0102 allele was observed in two patients and DRB1*0101 in six patients. Hereditary predisposition to RA in Sardinia therefore seems to be almost exclusively associated with the DRB1*0405 and DRB1*0101 alleles which share the 67LLEQRRAA74-85VG86 epitope in the peptide binding groove.
Keywords:disease susceptibility    ethnology    HLA-DR antigens    rheumatoid arthritis    Sardinia
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